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Titolo: HLA-DR,DQ and APOE genotypes and gender influence in Sardinian primary progressive MS
Autori: 
Data di pubblicazione: 2005
Rivista: 
NEUROLOGY  
Abstract: The authors examined the influence of APOE and human leukocyte antigen-DRB1-DQB1 polymorphisms on the course of multiple sclerosis in 871 patients, 773 with relapsing and 98 with primary progressive disease, and 348 control subjects. The risk of the primary progressive course was increased (odds ratio = 6.81, p = 0.002) in women carrying the APOE4 but not the DRB1-DQB1 predisposing genotype, suggesting in this subgroup of patients a reciprocal influence between these genes and gender in modulating clinical variability of the disease.
Handle: http://hdl.handle.net/11584/107281
Tipologia:1.1 Articolo in rivista

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