Protein Misfolding Lab. BL2 (Biosafety Level 2)
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Specifications: Lab. specialized to handle non conventional infectious agents which cause protein misfolding diseases.
Equipment available: 1 Laminar Flow Cabinet, 1 CO2 Incubator, 1 Refrigerator (+4/-20 °C), 1 Minicentrifuge, 1 Inverted Microscope, 1 FPLC, 1 Thermostatic Bath.
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Year of acquisition: 2004.
Responsabible: Prof. Alessandra Pani
Ownership: Department of Biomedical Sciences and Technologies Section of General Microbiology and Virology & Microbial Biotechnologies, University of Cagliari
Main applications:
♦ Design and evaluation of natural and synthesis compounds for anti-protein misfolding activity (Alzheimer ed Encefalopatie).
♦ Study of their mechanism of action.
♦ Evaluation of the effect of alterations in the metabolic/traffic of cholesterol on the protein misfolding process.
♦ Evaluation of anti-protein misfolding activity of cholesterol metabolism inhibitors, alone or in combination with anti- protein misfolding compounds.