High Resolution Mass Spectrometry Laboratory
Telephone: +39 070 6758617
Cell +39 380 4340125
Personal webpage: here
Principal areas of expertise: Food-omics and food safety; Clinical metabolomics; Development and applications of methods for metabolites identification and quantification by mass spectrometry
♦ Endeavours in metabolomics
Our metabolomics research field is focused on the high-throughput identification and quantification of small molecule metabolites that can be found in a cell, organ or organism and foods. These small molecules can include a range of endogenous and exogenous chemical entities such as peptides, amino acids, nucleic acids, carbohydrates, organic acids, vitamins, polyphenols, alkaloids, and just about any other chemical that can be used, ingested or synthesized by a given cell or organism. Metabolomics became possible because of recent technological breakthroughs in small molecule separation and identification. In our laboratories, these include robust, high-resolution mass spectrometry (LC-QTOF/MS) instruments for precise mass determination, triple and single quadrupoles (LC-MS/MS and GC/MS). Mass spectrometer data treatment include statistical comparisons and feature identification techniques such as unsupervised clustering (Principal Component Analysis or PCA) or supervised classification (Partial Least Squares Discriminant Analysis or PLS-DA).
Caboni P, Saba M, Oplos C, Aissani N, Maxia A, Menkissoglu-Spiroudi U, Casu L, Ntalli N (2014) Nematicidal activity of furanocoumarins from parsley against Meloidogyne spp. Pest Management Science: epub ahead of print, doi: 10.1002/ps.3890
Scano P, Murgia A, Pirisi FM, Caboni P (2014) A gas chromatography-mass spectrometry-based metabolomic approach for the characterization of goat milk compared with cow milk. Journal of Dairy Science: S0022-0302(14)00545-1.
Caboni P, Tronci L, Liori B, Tocco G, Sasanelli N, Diana A (2014) Tulipaline A: structure-activity aspects as a nematicide and V-ATPase inhibitor. Pesticide Biochemistry and Physiology 112: 33-39
Fanos V, Noto A, Caboni P, Pintus MC, Liori B, Dessì A, Mussap M (2014) Urine metabolomic profiling in neonatal nephrology. Clinical Biochemistry 47: 708-710
Fanos V, Caboni P, Corsello G, Stronati M, Gazzolo D, Noto A, Lussu M, Dessì A, Giuffrè M, Lacerenza S, Serraino F, Garofoli F, Serpero LD, Liori B, Carboni R, Atzori L (2014) Urinary (1)H-NMR and GC-MS metabolomics predicts early and late onset neonatal sepsis. Early Human Development 90 (Suppl 1): S78-83
Melis M, Carboni E, Caboni P, Acquas E (2013) Key role of salsolinol in ethanol actions on dopamine neuronal activity of the posterior ventral tegmental area. Addiction Biology: epub ahead of print, doi: 10.1111/adb.12097
Caboni P, Saba M, Tocco G, Casu L, Murgia A, Maxia A, Menkissoglu-Spiroudi U, Ntalli N (2013) Nematicidal activity of mint aqueous extracts against the root-knot nematode Meloidogyne incognita. Journal of Agricultural and Food Chemistry 61: 9784-9788