Telephone: +39 0706754711
Personal webpage: here
Principal areas of expertise: Occupational and environmental epidemiology; Molecular epidemiology; Cancer epidemiology
♦ Molecular epidemiology of Lymphomas
The Multicentre Italian Study on gene-environment interactions in Lymphoma etiology is being conducted in six Italian areas, with our group of the University of Cagliari as the leading unit. Having been awarded the PRIN 2007 grant (protocol N. 2007WEJLZB), the PRIN 2009 grant (protocol N. 20092ZELR2) and the 2010 Investigator Grant of the Italian Association for Research on Cancer (AIRC, IG 11855) with mention of excellence, and having thus promoted an unique Italian research group on lymphoma epidemiology, our Multicentre Italian Study participates to the InterLymph Consortium, initiated by the U.S. National Cancer Institute. InterLymph includes numerous international case-control studies on lymphoma; such a collaborative environment has allowed important scientific outbreaks, such as the role of polymorphisms in genes encoding for IL10 and TNF-alpha cytokines; the immune response against common infectious agents; the role of several autoimmune diseases; viral infections, such as hepatitis C; environmental exposure to immunotoxic polychlorobiphenils (PCB); and occupational exposure to ethylene oxide, benzene and trichloroethylene. A genome wide association study is currently in progress and epigenetic studies are being planned.
The successful candidate will conduct his project by strictly collaborating with the PI within the objectives of our project, addressing the interaction of gene polymorphisms, with epigenetic data, biomonitoring data, including the dioxin body burden, as well as detailed information on occupational and environmental exposures, individual habits, and clinical history. Survival analyses of lymphoma patients by their genetic profile, the chemotherapy protocol, clinical and pathological information, and lifestyle habits are also planned aiming to differentiate individual disease patterns and hopefully to design future individualized therapeutic schemes, based upon the polymorphisms of genes implicated in xenobiotic metabolism, DNA repair, or release of inflammatory cytokines. By conducting his research within this project, the candidate will acquire expertise in modern molecular epidemiology methods, including multivariate analysis using regression models and modified Cox proportional hazard models.
Cocco P, Vermeulen R, Flore V, Nonne T, Campagna M, Purdue M, Blair A, Monnereau A, Orsi L, Clavel J, Becker N, de Sanjosé S, Foretova L, Staines A, Maynadié M, Nieters A, Miligi L, ‘t Mannetje A, Kricker A, Brennan P, Boffetta P, Lan Q, Rothman N (2013) Occupational exposure to trichloroethylene and risk of non-Hodgkin lymphoma and its major subtypes: a pooled InterLymph analysis. Occup Environ Med, doi: 10.1136/oemed-2013-101551
Cocco P, Satta G, Dubois S, Pili C, Pilleri M, Zucca M, ‘t Mannetje AM, Becker N, Benavente Y, de Sanjosé S, Foretova L, Staines A, Maynadié M, Nieters A, Brennan P, Miligi L, Ennas MG, Boffetta P (2013) Lymphoma risk and occupational exposure to pesticides: results of the Epilymph study. Occup Environ Med 70: 91-98
Urayama KY, et al. (2012) Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups. J Natl Cancer Inst 104: 240-253
Conde L, et al. (2010) Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Nat Genet 42: 661-664
Rothman N, et al. (2006) Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph Consortium. Lancet Oncol 7: 27-38