Luigi M. Terracciano

 

Molecular Pathology DivisionTerracciano

Institute of Pathology

University Hospital Basel

Switzerland

Telephone: +41 61-265-28-49

Fax: +41 61-265-31-94

E-mail: lterracciano@uhbs.ch

Pricipal areas of expertise: Liver and gastrointestinal pathology; Molecular pathology; Liver neoplasia; Biomarkers; Cancer immunology

 

 

♦ Application of high-throughput techniques to the study of carcinogenesis

Prof. Luigi M. Terracciano has around 20 years of experience with histopathology, molecular pathology, translational research, experimental pathology and tissue bio-repositories. This combination of skills isdemonstrated by several publications focusing on biomarker expression in different neoplastic diseases. Professor Terracciano’s group at the University of Basel concentrates on the application of high-throughput techniques as tissue microarray, a technique for the first time developed in his Lab, to the study of pathology, in particular of gastrointestinal, liver, breast and head and neck neoplasia. Furthermore, the group of Prof. Luigi Terracciano, has a long time interest in HOX gene function in cancer development. Recently, Prof. Terracciano group The entire HOX gene network expression levels has been screened in a series of liver biopsies demonstrating that the HOXA locus represents the prevalent locus involved in hepatocarcinogenesis. Within HOXA genes, HOXA13 has been identified as the most up-regulated in hepatocellular carcinoma (HCC). Moreover, recent studies have found that dysregulated expression of  a long non-coding RNA named HOTTIP annoted within the four HOX loci pinpoints the spectrum of disease progressionof HCC  and may independently predict patient outcome.

 

Key publications:

Quagliata L, Matter MS, Piscuoglio S, Arabi L, Ruiz C, Procino A, Kovac M, Moretti F, Makowska Z, Boldanova T, Andersen JB, Hämmerle M, Tornillo L, Heim MH, Diederichs S, Cillo C, Terracciano LM (2013) lncRNA HOTTIP / HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients. Hepatology, doi: 10.1002/hep.26740

Andreozzi M, Quagliata L, Gsponer JR, Ruiz C, Vuaroqueaux V, Eppenberger-Castori S, Tornillo L, Terracciano LM (2013) VEGFA gene locus analysis across 80 human tumour types reveals gene amplification in several neoplastic entities. Angiogenesis, doi: 10.1007/s10456-013-9396-z

Cillo C, Schiavo G, Cantile M, Bihl MP, Sorrentino P, Carafa V, D’ Armiento M, Roncalli M, Sansano S, Vecchione R, Tornillo L, Mori L, De Libero G, Zucman-Rossi J, Terracciano LM (2011) The HOX gene network in hepatocellular carcinoma. Int J Cancer 129: 2577-2587

Hagiwara A, Cornu M, Cybulski N, Polak P, Betz C, Trapani F, Terracciano L, Heim MH, Rüegg MA, Hall MN (2012) Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c. Cell Metab 15: 725-738

Fischer C.A, Kampmann M, Zlobec I, Green E, Tornillo L, Lugli A, Wolfensberger M, Terracciano LM (2010) p16 expression in oropharyngeal cancer: its impact on staging and prognosis compared with the conventional clinical staging parameters. Ann Oncol 21: 1961-1966

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