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Titolo: A genome-wide association study of marginal zone lymphoma shows association to the HLA region
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Data di pubblicazione: 2015
Rivista: 
NATURE COMMUNICATIONS  
Abstract: Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x 10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
Handle: http://hdl.handle.net/11584/59042
Tipologia:1.1 Articolo in rivista

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