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Titolo: PROCONFLICT EFFECT OF CARBON-DIOXIDE INHALATION IN RATS
Autori: 
Data di pubblicazione: 1995
Rivista: 
LIFE SCIENCES  
Abstract: The effect of brief inhalation of carbon dioxide (CO2) was studied in a conflict situation (Vogel test) in the rat. This treatment, which inhibits gamma-aminobutyric acid (GABA) mediated transmission in rat brain and induces anxiety and panic attacks in humans, elicited a proconflict effect. Exposure of rats for 1 min to CO2 decreased by similar to 40% the number of Licking periods in the test. This effect was abolished by prior administration of alprazolam (0.5 mg per kilogram of body mass, i.p.). Although these results may support a role for GABA-mediated transmission in the anxiogenic effect of CO2 inhalation, the possibility that different neurotransmitters other than GABA are involved in the action of CO2 can not be ruled out.
Handle: http://hdl.handle.net/11584/39660
Tipologia:1.1 Articolo in rivista

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