Publications

 

Scopus Author

ResearcherID – Thomson Reuters

ORCID

Google Scholar Citations

 

Anagrafe della Ricerca

Titolo: Striato-nigral denervation increases type II benzodiazepine receptors in the substantia nigra of the rat.
Autori: 
Data di pubblicazione: 1986
Rivista: 
NEUROPHARMACOLOGY  
Citazione: Striato-nigral denervation increases type II benzodiazepine receptors in the substantia nigra of the rat. / Corda MG; Concas A; Porceddu ML; Sanna E; Biggio G.. - 25:1(1986), pp. 59-62.
Abstract: The degeneration of the striato-nigral projection induced by the injection of kainic acid into the striatum produced a 30% increase in the density of type II benzodiazepine binding sites (measured as the proportion of [3H]flunitrazepam which remained after the addition of 2 X 10(-7) M CL 218872). The lesion did not change the number of type I benzodiazepine binding sites (measured using [3H]ethyl-beta-carboline-3-carboxylate). The increase of type II benzodiazepine binding sites persisted and was markedly enhanced in the substantia nigra, previously lesioned with kainic acid. In fact, the injection of kainic acid into the nigra caused, 3 weeks after the treatment, a 80% decrease in the total number of type I benzodiazepine binding sites, and no change in the number of type II benzodiazepine binding sites. The density of type II sites increased by 70% following a subsequent injection of kainic acid into the striatum, homolateral to the lesioned substantia nigra. The results suggest that type I benzodiazepine binding sites in the nigra are located on kainic acid-sensitive elements (probably intrinsic neurones), while type II benzodiazepine binding sites, the number of which increased after degeneration of the striato-nigral pathway, are localized on kainic acid-resistant structures (probably axons or terminals) that receive an input from striatal afferents and from interneurones in the nigra.
Handle: http://hdl.handle.net/11584/36738
Tipologia:1.1 Articolo in rivista

File in questo prodotto:
Non ci sono file associati a questo prodotto.
credits unica.it | accessibilità Università degli Studi di Cagliari
C.F.: 80019600925 - P.I.: 00443370929
note legali | privacy

Nascondi la toolbar