| Titolo: | From (phenylsulfanyl)cycloalkanecarbaldehydes to optically active spirocyclic tetrahydrofurans: stereospecific resolution of symmetric aldehydes through (S)-proline-catalysed aldol reaction |
| Autori: | Rubanu MG
Sechi ML
Piras PP |
| Data di pubblicazione: | 2014 |
| Rivista: | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY |
| Abstract: | A variety of enantiomerically enriched tetrahydrofuran spirocyclic derivatives have been synthesised by a sequential enantioselective proline-induced stereospecific resolution through aldol reaction of (E/Z)-(phenylsulfanyl)cycloalkane-carbaldehydes followed by a ketone reduction, acid-catalysed [1,2]-SPh stereospecific migration, and ring-closure reaction. |
| Handle: | http://hdl.handle.net/11584/109801 |
| Tipologia: | 1.1 Articolo in rivista
|
