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Titolo: Physicochemical and rheological properties of a novel monoolein-based vesicle gelt
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Data di pubblicazione: 2013
Rivista: 
SOFT MATTER  
Abstract: The present paper deals with the preparation and characterization of an innovative vesicle-based gel composed of monoolein and lauroylcholine chloride. A number of vesicular formulations were prepared, in the range of 4-14 wt% of the dispersed phase, to investigate the system evolution from dilute uni-lamellar vesicles dispersion to a vesicle lipid gel. Morphology, thermal stability up to 55 °C, and viscoelastic properties, along with the effect of acid diclofenac inclusion within the formulation, were evaluated by cryo-TEM, SAXS, and rheological measurements. Moreover, the nanostructure of the vesicle dispersion obtained upon gel dilution in water was assessed by cryo-TEM and SAXS, while DLS was used to monitor the formulation stability (size and -potential). All the collected results lead to the conclusion that this new vesicle-based gel displays all the requirements needed for application in the pharmaceutical and cosmetic fields.
Handle: http://hdl.handle.net/11584/91594
Tipologia:1.1 Articolo in rivista

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