Research Projects

 

La nostra ricerca sui canali intracellulari e sul Covid-19:

I canali ionici come bersaglio di farmaci antivirali

Il canale umano TPC1 e il meccanismo di conduzione degli ioni sodio (in giallo il filtro selettivo,

in arancio il filtro idrofobico, in stick la molecola che attiva il canale, il phosphatidylinositol 3,5-bisphosphate). Lo ione sodio (in blu) diffonde lungo il poro solvatato da 5-6 molecole di acqua.

 

Running Projects

– PRIN (2015-2018): Interfacing organelles and cell physiology via ion channels: from biophysics to therapy

 

Past Projects

– IMI ND4BB Topic 2 (2013-2017): Learning from success and failure & Getting Drugs into Bad Bugs

Molecular Basis of the Bacterial Cell Wall Permeability, WP2 Leader: Understanding the impact of Porin structure and intrinsic permeability

– ITN Marie Sklodowska Curie (2013-2017): Molecular Basis of Antibiotic Translocation

– PRIN (2012-2015): Intracellular channels and pores: structural and functional studies provide new rules for engineering artificial channels.

– RTN Marie Curie 2006-2009: Translocation

– IIF Marie Curie (2010-2012): AQPAssoc, Coordinator

 

HPC Infrastructure:

With additional 64 TB of storage (left) we completed the high performance computing infrastructure dedicated to research  for future antibiotics generation (see at www.transloction.eu): 16 workstations equipped with 4 last generation Titan GPUs each and 200 TB storage for backup, all stored at the Department of Physics, Universita degli Studi di Cagliari.

IMG_0960 IMG_0961

 

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