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Titolo: Synthesis Stereochemical Separation and Biological Evaluation of Selective Inhibitors of Human MAO-B: 1-(4-Arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines
Autori: 
Data di pubblicazione: 2010
Rivista: 
JOURNAL OF MEDICINAL CHEMISTRY  
Citazione: Synthesis Stereochemical Separation and Biological Evaluation of Selective Inhibitors of Human MAO-B: 1-(4-Arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines / F. Chimenti; D. Secci; A. Bolasco; P. Chimenti; A. Granese; S. Carradori; M. Yanez; F. Orallo; M.L. Sanna; B. Gallinella; R. Cirilli. - 53:17(2010), pp. 6516-6520.
Abstract: Novel 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazine derivatives have been investigated for their ability to inhibit selectively the activity of the human B isoform of monoamine oxidase. These compounds were obtained as racemates and (R)-enantiomers by a stereoconservative synthetic pattern in high yield and enantiomeric excess. The (S)-enantiomers of the most active derivatives have been separated by enantioselective HPLC. All compounds showed selective activity against hMAO-B with IC(50) ranging between 21.90 and 0.018 mu M.
Handle: http://hdl.handle.net/11584/88125
Tipologia:1.1 Articolo in rivista

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