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Titolo: Synthesis and characterization of new phthalhydrazothiazole derivatives: A preliminary investigation on their activity against hepatocellular carcinoma
Autori: 
Data di pubblicazione: 2009
Rivista: 
JOURNAL OF HETEROCYCLIC CHEMISTRY  
Abstract: The synthesis of new 2-(4-substituted thiazol-2-yl)-2,3-dihydrophthalazine-1,4-diones, 2-(4-oxo-4,5-dihydro-thiazol-2-yl)-2,3-dihydrophthalazine-1,4-diones, and 2-(5-arylidene-4-oxo-4,5-dihydrothiazol-2-yl)-2,3-dihy-drophthalazine-1, 4-diones is reported. The introduction of different substituents on the phthalazine, the thiazole and the thiazolinone has been studied. The new compounds have been characterized and evaluated for their antiproliferative activity against hepatocellular carcinoma, one of the most lethal tumors. The activity shown by some of these compounds towards liver tumor cells is encouraging.
Handle: http://hdl.handle.net/11584/106767
Tipologia:1.1 Articolo in rivista

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