Approaches for Identification of Antiviral
Agents Summer School (IAAASS)
September 30 – October 4, 2012
Santa Margherita di Pula, Sardinia
Provisional Program
Sunday, September 30th – Registration Day
13:00 pm Buffet lunch
Afternoon – Free
7.00 pm Welcoming Remarks
7.15 pm Development of new antiviral agents: from peptides to small molecules, Giorgio Palù, University of Padova, Italy
8.00 pm Informal Dinner
Monday, October 1st
Breakfast
Morning session
Plenary lectures
9.00 – 9.45 am A dynamic interplay between HIV-1 integrase subunits as a new therapeutic target, Mamuka Kvaratskhelia, The Ohio State University, Columbus, USA.
9.55 – 10.40 am Influenza viruses and host cell signaling – towards identification of novel targets for antiviral therapy, Stephan Ludwig, University of Muenster, Germany.
10.50 – 11.10 am Coffee break
11:15 – 12.00 pm Multi-targeting with one single drug, Peter Matyus, Semmelweis University, Hungary
12.10 – 12:55 pm Therapy of Human Cytomegalovirus – actual situation, problems and future perspectives, Thomas Mertens, Universitätsklinikum Ulm, Germany
1:00 pm Lunch
Afternoon session
3.30 – 5:00 pm Thematic Group Discussions
5:00 – 6.00 pm Coffee break/ Poster Session 1
Short Talks
6.00 – 6.15 pm From a Protein Crystal to an Effective Hepatitis C Vaccine: The Hard Way of Structural Biology, Valeria Fadda, University of St Andrews, St Andrews (UK)
6.15 – 6.30 pm Structural and functional analysis of a dendrimer microbicide against HIV-1 env, Cath Latham, Burnet Institute, Australia
6.30 – 6.45 pm Study of the role of gp120 disulfide bridges and N-glycans in HIV capture and transmission, Leen Mathys, Rega Institute for Medical Research, Belgium
6.45 – 7.00 pm Synthesis and biological evaluation of new dual inhibitors of HIV-1 associated functions, Rita Meleddu, University of Cagliari, Italy.
8:30 pm Sardinian Dinner
Tuesday, October 2nd
Breakfast
Morning session
9.00 – 9.45 am Can novel antiretroviral strategies be deduced from the study of host-retrovirus interplay recorded in vertebrate genomes? Jonas Blomberg, Uppsala University, Sweden.
9.55 – 10.40 am Feature-based Pharmacophores for Rapid Compound Profiling, Thierry Langer, Prestwick Chemical SAS, Strasbourg-Illkirch, France
10.50 – 11.10 am Coffee break
11:15 – 12.00 pm HIV/AIDS: One virus (HIV-1) and two challenging targets (GP120 and RT dimerization). Strategies for the design and discovery of inhibitors, María José Camarasa, Instituto de Qímica Médica (IQM-CSIC), Madrid, Spain
12.10 – 12:55 pm A Small Molecule Platform to Inhibit HIV through the Nucleocapsid Protein, Daniel H. Appella, National Institutes of Health, Bethesda, MD, USA
1:00 pm Lunch
Afternoon session
3.30 – 5:00 pm Thematic Group Discussions
5:00 – 6.00 pm Coffee break/ Poster Session 2
Short Talks
6.00 – 6.15 pm The mechanism of action of new HIV-1 reverse transcriptase dual inhibitors explored by kinetic studies and site direct mutagenesis, Angela Corona, University of Cagliari, Italy
6.15 – 6.30 pm Optimization of an in vitro assay to quantify HIV-1 Reverse Transcriptase (RT) dimerization, Tania Matamoros, Centro de Biología Molecular “Severo Ochoa”, CSIC-UAM, Madrid, Spain
6.30 – 6.45 pm Formation of HCV replication complex on membranous web: An interplay between viral and cellular factors, Vikas Saxena, Academia Sinica, Taipei, Taiwan
6.45 – 7.00 pm Transmitted and secondary antiretroviral drug resistance among Ethiopian patients, Andargachew Mulu Meharie, University of Leipzig, Leipzig, Germany
8:30 pm Sardinian Dinner
Wednesday, October 3rd
Breakfast
Morning session
9.00 – 9.45 am G-quadruplex nucleic acid conformations: potentially selective targets against viral and cancer diseases, Stefano Alcaro, Università “Magna Græcia” di Catanzaro, Italy
9.55 – 10.40 am High Throughput Screening for Inhibitors of Human Immunodeficiency Virus Ribonuclease H Activity, Stuart F.J. Le Grice, NCI, Frederick, MD, USA
10.50 – 11.10 am Coffee break
11:15 – 12.00 pm Innate Immunity and RNA viruses, Ali Mirazimi, Karolinska Institute, Sweden
12.10 – 12:55 pm to be announced
1:00 pm Lunch
Afternoon session
3.30 – 5:00 pm Thematic Group Discussions
5:00 – 6.00 pm Coffee break/ Poster Session 2
Short Talks
6.00 – 6.15 pm Biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and resistance mutations M41L, L210W and T215Y, Gilberto Betancor, Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), Madrid, Spain
6.15 – 6.30 pm Characterization of retroviral resistance mechanisms against azidothymidine, Anna Schneider, Department of Biopolymers, University of Bayreuth, Germany
6.30 – 6.45 pm The Ephrin Receptor Tyrosine Kinase A2 is a Cellular Receptor for Kaposi’s Sarcoma-Associated Herpesvirus, Saipraisad Salvi, Institut für Klinische und Molekulare Virologie, Erlangen, Germany
6.45 – 7.00 pm Ebola virus recombinant VP35 (rVP35) as a paradigm model for dsRNA binding-mediated suppression of the interferon-α/β innate immune response, Luca Zinzula, University of Cagliari, Italy
Final remarks
8:30 pm Gala Dinner
Thursday, October 4th- Breakfast and Departure