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Titolo: New Adaptive Chiral Thiophene Ligands for Copper-Catalyzed Asymmetric Henry Reaction
Data di pubblicazione: 2009
Abstract: A new type of adaptive chiral thiophene-based ligands 3 has been designed and developed. The synthetic flexibility of the thienyl ring allowed for the preparation of polydendate C2-symmetric ligands in good yields, carrying simultaneously "hard" as well as "soft" coordinating atoms (i.e., N, S). The coordination attitude of 3 was then tested in the enantioselective base-free Cu(OAc)(2)-catalyzed addition of nitromethane to aromatic aldehydes, leading to the corresponding P-nitro alcohols in excellent yields and enantiomeric excesses up to 86%. Chirality 21:239-244, 2009. (c) 2008 Wiley-Liss, Inc.
Tipologia:1.1 Articolo in rivista

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