Lista delle Pubblicazioni più recenti (2010-2020):

BALDISSEROTTO A, DEMURTAS M, LAMPRONTI I, TACCHINI M, MOI D, BALBONI G, PACIFICO S, VERTUANI S, MANFREDINI S, ONNIS V. (2020) Synthesis and evaluation of antioxidant and antiproliferative activity of 2-arylbenzimidazoles. BIOORG. CHEM. Vol. 94, art. numb. 103396.

NOCENTINI A, MOI D, DEPLANO A, OSMAN SM, ALOTHMAN ZA, BALBONI G, SUPURAN CT, ONNIS V. (2020) Sulfonamide/sulfamate switch with a series of piperazinylureido derivatives. Synthesis, kinetic and in silico evaluation as carbonic anhydrase isoforms I, II, IV and IX inhibitors. EUR. J. MED. CHEM. Vol. 186, art. numb. 111896.

MOI D,NOCENTINI A, DEPLANO A, BALBONI G, SUPURAN CT, ONNIS V. (2019) Structure-activity relationship with pyrazole-based aromatic sulfamates as carbonic anhydrase isoforms I, II, IX and XII inhibitors: Synthesis and biological evaluation. EUR. J. MED. CHEM. Vol. 182, art. numb. 111638.

MOSCHETTI G, AMODEO G, PALADINI MS, MOLTENI R, BALBONI G, PANERAI A, SACERDOTE P, FRANCHI S. (2019) Prokineticin 2 promotes and sustains neuroinflammation in vincristine treated mice: Focus on pain and emotional like behavior. BRAIN BEHAV. IMMUN. Vol. 82, p. 422-431.

PAUL A, VISWANATHAN GK, MAHAPATRA S, BALBONI G, PACIFICO S, GAZIT E, SEGAL D. (2019) Antagonistic activity of naphthoquinone-based hybirds toward amyloids associated with Alzheimer’s disease and type-2 diabetes. ACS CHEM. NEUROSCI. Vol. 10, p. 3510-3520.

MOI D, FOSTER PA, RIMMER LG, JAFFRI A, DEPLANO A, BALBONI G, ONNIS V, POTTER BVL. (2019) Synthesis and in vitro evaluation of piperazinyl-ureido sulfamates as steroid sulfatase inhibitors. EUR. J.MED.CHEM. vol. 182, art. numb. 111614.

MAFTEI D, RATANO P, FUSCO I, MARCONI V, SQUILLACE S, NEGRI L, SEVERINI C, BALBONI G, STEARDO L, BRONZUOLI MR, SCUDERI C, CAMPOLONGO P, LATTANZI R. (2019) The prokineticin receptor antagonist PC1 rescues memory impairment induced by beta amyloid administration through the modulation of prokineticin system. NEUROPHARMACOLOGY vol. 158, art. numb. 107739.

MOSCHETTI G,AMODEO G, MAFTEI D, LATTANZI R, PROCACCI P, SARTORI P, BALBONI G, ONNIS V, CONTE V, PANERAI A, SACERDOTE P, FRANCHI S. (2019) Targeting prokineticin system counteracts hypersensitivity, neuroinflammation, and tissue damage in a mouse model of bortezomib-induced peripheral neuropaty. J. NEUROINFLAMMATION Vol. 16, art. numb. 89.

DEMURTAS M, BALDISSEROTTO A, LAMPRONTI I, MOI D, BALBONI G, PACIFICO S, VERTUANI S, MANFREDINI S, ONNIS V. (2019) Indole derivatives as multifunctional drugs: synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones. BIOORG. CHEM. Vol. 85, p. 568-576.

POLO S, DIAZ AF, GALLARDOU N, LEANEZ S, BALBONI G, POL O. (2019) Treatment with the delta opioid agonist UFP-512 alleviates chronic inflammatory and neuropathic pain: mechanisms implicated. FRONT PHARMACOL. Vol. 10, art. numb: 283.

XU Y, ZHI F, PENG Y, SHAO N, KHIATI D, BALBONI G, YANG Y, XIA Y. (2019) d-Opioid receptor activation attenuates hypoxia/MPP+-induced downregulation of PINK1: a novel mechanism of neuroprotection against parkinson injury. MOL. NEUROBIOL. Vol. 56, p. 252-266.

BALDISSEROTTO A, DEMURTAS M, LAMPRONTI I, MOI D, BALBONI G, VERTUANI S, MANFREDINI S, ONNIS V. (2018) Benzofuran hydrazones as potential scaffold in the development of multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity. EUR. J. MED. CHEM. Vol. 156, p. 118-125.

NOCENTINI A, MOI D, BALBONI G, SALVADORI S, ONNIS V, SUPURAN CT. (2018) Synthesis and biological evaluation of novel pyrazoline-based aromatic sulfamates with potent carbonic anhydrase isoforms II, IV and IX inhibitory efficacy.  BIOORG. CHEM. vol. 77, p. 633-639.

NOCENTINI A, MOI D, BALBONI G, ONNIS V, SUPURAN CT. (2018) Discovery of thiazolin-4-one-based aromatic sulfamates as a new class of carbonic anhydrase isoforms I, II, IV and IX inhibitors. BIOORG. CHEM. vol.77, p.293-299.

TRABOULSI W, SERGENT F, BOUFETTAL H, BROUILLET S, SLIM R, HOFFMANN P, BENLAHFID M, ZHOU QY, BALBONI G, ONNIS V, BOLZE PA, SALOMON A, SAUTHIER P, MALLET F, ABOUSSAOUIRA T, FEIGE JJ, BENHAROUGA M, ALFAIDY N. (2017) Antagonism of EG-VEGF receptors as targeted therapy for choriocarcinoma progression in vitro and in vivo. CLIN. CANCER RES. vol. 23, p. 7130-7140.

KANG MG, PARK J, BALBONI G, LIM MH, LEE C, RHEE HW. (2017) Genetically encodable bacterial flavin transferase for fluorogenic protein modification in mammalian cells. ACS SYNTH BIOL. vol. 6, p. 667-677.

PARK B, NAM JH, KIM JH, KIM HJ, ONNIS V, BALBONI G, LEE KT, PARK JH, CATTO M, CAROTTI A, LEE JY. (2017) 3,4-Dihydroquinazoline derivatives inhibit the activities of cholinesterase enzymes. BIOORG. MED. CHEM. LETT., vol. 27, p. 1179-1185.

CAIOLI S, SEVERINI C, CIOTTI T, FLORENZANO F, PIMPINELLA D, PETROCCHI PASSERI P, BALBONI G, POLISCA P, LATTANZI R, NISTICO’ R, NEGRI L, ZONA C. (2017) Prokineticin system modulation as a new target to counteract the amyloid beta toxicity induced by glutamatergic alterations in an in vitro model of Alzheimer’s disease. NEUROPHARMACOLOGY, vol. 116, p. 82-97.

CHAO D, WANG Q, BALBONI G, DING G, XIA Y. (2016) Attenuating ischemic disruption of K+ homeostasis in the cortex of hypoxic-ischemic neonatal rats: DOR activation vs. acupuntare treatment. MOL. NEUROBIOL., vol. 53, p. 7213-7227.

LANDUCCI E, LATTANZI R, GERACE E, SCARTABELLI T, BALBONI G, NEGRI L, PELLEGRINI-GIAMPIETRO DE. (2016) Prokineticins are neuroprotective in models of cerebral ischemia and ischemic tolerance in vitro. NEUROPHARMACOLOGY, vol. 108, p. 39-48.

ONNIS V, DEMURTAS M, DEPLANO A, BALBONI G, BALDISSEROTTO A, MANFREDINI S, PACIFICO S, LIEKENS S, BALZARINI J. (2016) Design, synthesis and evaluation of antiproliferative activity of new benzimidazolehydrazones. MOLECULES, vol. 21, pii: E579.

M’DAHOMA S, GADOTTI VM, ZHANG FX, PARK B, NAM JH, ONNIS V, BALBONI G, LEE JY, ZAMPONI G. (2016) Effect of the T-type channel blocker KYS-05090S in mouse models of acute and neuropathic pain. PFLUGERS ARCH., vol. 468, p. 193-199.

SAKAKIBARA N, BALBONI G, CONGIU C, ONNIS V, DEMIZU Y, MISAWA T, KURIHARA M, KATO Y, MARUYAMA T, TOYAMA M, OKAMOTO M, BABA M. (2015) Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives. ANTIVIR. CHEM. CHEMOTHER., vol. 24, p. 62-71.

SEVERINI C, LATTANZI R, MAFTEI D, MARCONI V, CIOTTI MT, PETROCCHI PASSERINI P, FLORENZANO F, DEL DUCA E, CAIOLI S, ZONA C, BALBONI G, SALVADORI S, NISTICÒ R, NEGRI L. (2015) Bv8/Prokineticin 2 is involved in Abeta-induced neurotoxicity. SCIENTIFIC REPORTS, vol. 5, article number 15301.

CONGIU C, ONNIS V, DEPLANO A, BALBONI G, CERUSO M, SUPURAN CT. (2015) Synthesis and carbonic anhydrase I, II, IX AND XII inhibitory activity of sulfamates incorporating piperazinyl-ureido moieties. BIOORG. MED. CHEM., vol. 23, p. 5619-5625.

CONGIU C, ONNIS V, DEPLANO A, BALBONI G, DEDEOGLU N, SUPURAN CT. (2015) Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase i, II, IX and XII inhibitory activity. BIOORG. MED. CHEM. LETT., vol. 25, p.3850-3853.

DE PETROCELLIS L, SCHIANO-MORIELLO A, BYUN JS, SOHN JM, LEE JY, VAZQUEZ-ROMERO A, GARRIDO M, MESSEGUER A, ZHANG F-X, ZAMPONI GW, DEPLANO A, CONGIU C, ONNIS V, BALBONI G, DI MARZO V. (2015) Inhibitory effect of positively charged triazine antagonists of prokineticin receptors on the transient vanilloid type-1 (TRPV1) channel. PHARMACOLOGICAL RESEARCH, vol. 99, p. 362-369.

CONGIU C, ONNIS V, BALBONI G, SCHIANO-MORIELLO A, DI MARZO V, DE PETROCELLIS L. (2015) TRPV1 modulators: Synthesis and in vitro evaluation of 1-heteroarylpiperidinecarboxamide and piperazinylurea derivatives. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.100, p. 129-138.


CAO S; CHAO D; ZHOU H; BALBONI G; XIA Y. (2015) A novel mechanism for cytoprotection against hypoxic injury: delta-opioid receptor-mediated increase in Nrf2 translocation. BR. J. PHARMACOL.vol. 172, p. 1869-1881.

LATTANZI R; MAFTEI D; MARCONI V; FLORENZANO F; FRANCHI S; BORSANI E; RODELLA LF; BALBONI G; SALVADORI S; SACERDOTE P; NEGRI L. (2015) Prokineticin 2 upregulation in the peripheral nervous system has a major role in triggering and maintaining neuropathic pain in the chronic constriction injury model. BIOMED RESEARCH INTERNATIONAL, vol. 2015, article ID 301292.

GUIDA F; LATTANZI R; BOCCELLA S; MAFTEI D; ROMANO R; MARCONI V; BALBONI G; SALVADORI S; SCAFURO MA; DE NOVELLIS V; NEGRI L; MAIONE S; LUONGO L. (2015) PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice. PHARMACOLOGICAL RESEARCH, vol. 91, p. 36-46.

LIANG J; CHAO D; SANDHU HK; YU Y; ZHANG L; BALBONI G; KIM DH; XIA Y. (2014) Delta-opioid receptors up-regulate excitatory amino acid transporter in mouse astrocytes. BRITISH JOURNAL PHARMACOLOGY, vol. 171, p. 5417-5430.

LATTANZI R; CONGIU C; ONNIS V; DEPLANO A; SALVADORI S; MARCONI V; MAFTEI D; FRANCIOSO A; AMBROSIO C; CASELLA I; COSTA T; CALTABIANO G; MATSOUKAS MT; BALBONI G; NEGRI L. (2014) Halogenated trizinediones behave as antagonists of PKR1: in-vitro and in-vivo pharmacological characterization. INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, vol. 5, p. 5064-5072.

DE TOMA AS; KRISHNAMOORTHY J; NAM Y; JIN LEE H; BRENDER JR; KOCHI A; LEE D; ONNIS V; CONGIU C; MANFREDINI S; VERTUANI S; BALBONI G; RAMAMOORTHY A; LIM MH. (2014) Interaction and reactivity of synthetic aminoisoflavones with metal-free and metal-associated amyloid-beta. CHEMICAL SCIENCE, vol. 5 p. 4851-4862.

MAFTEI D; MANCONI V; FLORENZANO F; GIANCOTTI LA; CASTELLI M; MORETTI S; BORSANI E; RODELLA LF; BALBONI G; LUONGO L; MAIONE S; SACERDOTE P; NEGRI L; LATTANZI R. (2014) Controlling the activation of the Bv8/prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals. BRITISH JOURNAL OF PHARMACOLOGY, vol. 171, p. 4850-4865.

KABLI N; NGUYEN T; BALBONI G; O’DOWD BF; GEORGE SR. (2014) Antidepressant-like and anxiolytic-like effects following activation of the mu-delta opioid receptor heteromer in the nucleus accumbens. MOLECULAR PSYCHIATRY, vol. 19, p, 986-994.

CONGIU C; ONNIS V; DEPLANO A; SALVADORI S; MARCONI V; MAFTEI D; NEGRI L; LATTANZI R; BALBONI G. (2014) A new convenient synthetic method and preliminary pharmacological characterization of triazinediones as prokineticin receptor antagonists. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 81, p. 334-340.

CONGIU C; ONNIS V; BALBONI G; SUPURAN CT (2014) Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)-one/thione moieties. BIOORGANIC & MEDICINAL
CHEMISTRY LETTERS, vol. 24, p. 1776-1779.

CHARFI I; NAGI K; MNIE-FILALI O; THIBAULT D; BALBONI G; SCHILLER PW; TRUDEAU LE; PINEYRO G. Ligand- and cell-dependent determinants of internalization and cAMP modulation by delta opioid receptor (DOR) agonists. (2014) CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 71, p. 1529-1546.

HE X, YANG Y, ZHI F, MOORE ML, KANG X, CHAO D, WANG R, BALBONI G, SALVADORI S, KIM DH, XIA Y. (2013) Delta-opioid receptor activation modified microRNA expression in the rat kidney under prolonged hypoxia. PLOS ONE, vol. 8, e61080.

LESMA G, SALVADORI S, AIRAGHI F, BOJNIK E, BORSODI A, RECCA T, SACCHETTI A, BALBONI G, SILVANI A. (2013) Synthesis, pharmacological evaluation and conformational investigation of endomorphin-2 hybrid analogues. MOLECULAR DIVERSITY, vol. 17, p. 19-31.

CRICHARD-LALONDE M, NAGI K, AUDET N, SLENO R, AMRAEI M, HOGUE M, BALBONI G, SCHILLER P W, BOUVIER M, HÉBERT T E, PINEYRO G. (2013) Conformational dynamics of KIR3.1/KIR3.2 channel activation via delta-opioid receptors. MOLECULAR PHARMACOLOGY, vol. 83, p. 416-428.

CHAO D, HE X, YANG Y, BALBONI G, SALVADORI S, KIM DH, XIA Y. (2012) Hydrogen sulfide induced disruption of Na+ homeostasis in the cortex. TOXICOLOGICAL SCIENCES, vol. 128, p. 198-208.

CHAO D, HE X, YANG Y, BAZZY-ASAAD A, LAZARUS LH, BALBONI G, KIM DH, XIA Y. (2012) DOR activation inhibits anoxic/ischemic Na+ influx through Na+ channels via PKC mechanisms in the cortex. EXPERIMENTAL NEUROLOGY. vol 236; p. 228-239.

WALL R J, HE G, DENISON M S, CONGIU C, ONNIS V, FERNANDES A, BELL D R, ROSE M, CRAIG ROWLANDS J, BALBONI G, MELLOR I R. (2012) Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context. TOXICOLOGY. vol. 297; p. 26-33.

BALBONI G, CONGIU C, ONNIS V, MARESCA A, SCOZZAFAVA A, WINUM J-Y, MAIETTI A, SUPURAN CT. (2012) Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins.

JACOBSON O, WEISS ID, NIU G, BALBONI G, CONGIU C, ONNIS V, KIESEWETTER DO, LATTANZI R, SALVADORI S, CHEN X. (2011) Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain. THE JOURNAL OF NUCLEAR MEDICINE. vol. 52; p. 600-607.

BALBONI G, SALVADORI S, MARCZAK  E. D, KNAPP J. M, LAZARUS L. H, PENG X, SI Y. G, NEUMEYER J. L. (2011) Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. vol. 46; p. 799-803.

KABLI N, MARTIN N, FAN T, NGUYEN T, HASBI A, BALBONI G, O’DOWD BF, GEORGE SR. (2010) Agonists at the delta-opioid receptor modify the binding of mu-receptor agonists to the mu-delta receptor hetero-oligomer. BRITISH JOURNAL OF PHARMACOLOGY. vol. 161; p. 1122-1136.

BALBONI G, MARZOLA E, SASAKI Y, AMBO A, MARCZAK E. D, LAZARUS L. H, SALVADORI S. (2010) Role of 2′,6′-dimethyl-L-tyrosine (Dmt) in some opioid lead compounds. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18; p. 6024-6030.

BALLET S, MARCZAK E D, FEYTENS D, SALVADORI S, SASAKI Y, ABELL A. D, LAZARUS L. H, BALBONI G., TOURWE’ D. (2010) Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20; p. 1610-1613.

BALBONI G., SALVADORI S., TRAPELLA C., KNAPP B. I., BIDLACK J. M., LAZARUS L. H., PENG X., NEUMEYER J. L. (2010) Evolution of the bifunctional lead mu agonist / delta antagonist containing the 2′,6′-dimethyl-L-tyrosine-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Dmt-Tic) opioid pharmacophore. ACS CHEMICAL NEUROSCIENCE, vol. 1; p. 155-164.


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