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Titolo: L-Dopa stimulates c-fos expression in dopamine denervated striatum by conbined activation of D-1 and D-2 receptors
Autori: 
Data di pubblicazione: 1993
Rivista: 
BRAIN RESEARCH  
Citazione: L-Dopa stimulates c-fos expression in dopamine denervated striatum by conbined activation of D-1 and D-2 receptors / Morelli M; Cozzolino A; Pinna A; Fenu S; Carta A; Di Chiara G. - In: BRAIN RESEARCH. - ISSN 0006-8993. - 623:2(1993), pp. 334-336.
Abstract: Administration Of L-dopa to unilaterally 6-hydroxydopamine-lesioned rats, activates the early gene c-fos in the lesioned caudate-putamen. D-1 receptor blockade by SCH 23390, prevented L-dopa-induced Fos-like immunoreactivity in the whole caudate-putamen, while D-2 receptor blockade by raclopride reduced Fos-like immunoreactivity only in the dorso-lateral portion. The results suggest that L-dopa induces c-fos primarily through an activation of D-1 receptors, while D-2 receptor stimulation plays a facilitatory influence on D-1-mediated c-fos expression.
Handle: http://hdl.handle.net/11584/95765
Tipologia:1.1 Articolo in rivista

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