Prodotti della ricerca

Titolo: Structure-based approaches applied to the study of pharmaceutical relevant targets
Data di pubblicazione: 24-mar-2016
Abstract: Computer Aided Drug Design/Discovery methods became complementary to traditional and modern drug discovery approaches. Indeed CADD is useful to improve and speed up the detection and the optimization of bioactive molecules. The present study is focused on the application of structure-based approaches to the study of pharmaceutical relevant targets. The introduction provides a quick overview on the fundamentals of computational chemistry and structure-based methods, while in the successive chapters the main targets investigated through these methods are treated. In particular we focused our attention on Reverse Transcriptase of HIV-1, Monoamine oxidase B and VP35 of Ebola virus. The last chapter is dedicated to the validation of covalent docking performed with Autodock.
Tipologia:8.2 Tesi di dottorato (ePrints)

File in questo prodotto:
PhD_Thesis_GiuliaBianco.pdf Tesi di dottoratoNon specificatoOpen Access Visualizza/Apri
credits | accessibilità Università degli Studi di Cagliari
C.F.: 80019600925 - P.I.: 00443370929
note legali | privacy

Nascondi la toolbar