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| Titolo: | Brain benzodiazepine receptors increase after chronic ethyl-beta-carboline-3-carboxylate. |
| Autori: | |
| Data di pubblicazione: | 1983 |
| Rivista: | |
| Abstract: | Rats were treated with repeated intraventricular injections of ethyl-beta-carboline-3-carboxylate (beta-CCE) (10 micrograms/rat, twice daily for 8 days), 36 h after the last injection, the total number of 3H-diazepam binding sites was increased in the cerebral cortex, cerebellum and hippocampus by 63, 51 and 38%, respectively. On the other hand, there were no significant differences in the dissociation constants (KD) between beta-CCE and solvent treated rats. In contrast, chronic beta-CCE administration failed to change the number of the apparent affinity of 3H-beta-CCE binding sites in all the brain areas examined. The results suggest that beta-CCE is an antagonist at the 3H-diazepam binding sites. |
| Handle: | http://hdl.handle.net/11584/35644 |
| Tipologia: | 1.1 Articolo in rivista |
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