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Titolo: Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis
Autori: 
Data di pubblicazione: 2010
Rivista: 
NATURE GENETICS  
Abstract: A genome-wide association scan of approximately 6.6 million genotyped or imputed variants in 882 Sardinian individuals with multiple sclerosis (cases) and 872 controls suggested association of CBLB gene variants with disease, which was confirmed in 1,775 cases and 2,005 controls (rs9657904, overall P = 1.60 x 10(-10), OR = 1.40). CBLB encodes a negative regulator of adaptive immune responses, and mice lacking the ortholog are prone to experimental autoimmune encephalomyelitis, the animal model of multiple sclerosis.
Handle: http://hdl.handle.net/11584/99221
Tipologia:1.1 Articolo in rivista

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