|Titolo:||Modulation of lipid metabolism and vitamin A conjugated linoleic acid|
CARTA, GIANFRANCA (Primo)
|Data di pubblicazione:||2002|
|Abstract:||Summary The termconjugatedlinoleic acid (CLA) refers to a collection of positional and geometrical isomers of octadecadienoic acid with conjugated double bonds. CLAhas been shown to posses several beneficial activitiesin different experimental models, however, out of 28 isomers only two, c9, t11and t10, c12 have been thus far demonstrated to be biologicallyactive. The discovery that it can be elongated and desaturated as a regular fattyacid in human and animal tissues brought a newpossibility that its activity may be related to its properties as a peculiar unsaturated fatty acid. In fact, CLAis able to be incorporated in lipid classes as oleic acid, accumulatingin those tissues rich in neutral lipids; to be metabolized as linoleic acid and so influencing linoleic acid desaturation and elongation; and to be beta oxidized in peroxisomes which may account for, through activation of PPARs, its ability to increase free retinol levels and influence gene expression. These activities are amplified where CLAaccumulates more such as mammaryand adipose tissues and may explain its peculiar beneficial properties, at relativelowdietary concentrations, inthese tissues. Furthermore, it hasbeen demonstrated that CLAcan be endogenously formed by delta 9 desaturation of vaccenic acid (t1118:1) thus forming the isomer c9, t11. Either endogenously formed or through dietary intake, CLAshowed to be metabolized in the same way and to exert the same biological properties.We may conclude that a regular intake of CLA, or/and vaccenic acid asits precursor, should work as an excellent preventiveagent bymodulatinglipidmetabolismintarget tissuesthusconferringprotectionagainst theattackof insultsof different type. &2002 Elsevier Science Ltd. All rights reserved.|
|Tipologia:||1.1 Articolo in rivista|
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