Pubblicazioni

 

Pubblicazioni recenti:

Structure-activity relationship with pyrazoline-based aromatic sulfamates as carbonic anhydrase isoforms I, II, IX and XII inhibitors: synthesis and biological evaluation
Davide Moi, Alessio Nocentini, Alessandro Deplano, Gianfranco Balboni, Claudiu T. Supuran, Valentina Onnis
European Journal of Medicinal Chemistry, 182 (2019) 111638

Synthesis and in vitro evaluation of piperazinyl-ureido sulfamates as steroid sulfatase inhibitors
Davide Moi, Paul A. Foster, Lucy G. Rimmer, Alisha Jaffri, Alessandro Deplano, Gianfranco Balboni, Valentina Onnis , Barry V.L. Potter
European Journal of Medicinal Chemistry, 182 (2019) 111614

Targeting prokineticin system counteracts hypersensitivity, neuroinflammation, and tissue damage in a mouse model of bortezomib-induced peripheral neuropathy
Giorgia Moschetti, Giada Amodeo, Daniela Maftei, Roberta Lattanzi, Patrizia Procacci, Patrizia Sartori, Gianfranco Balboni, Valentina Onnis, Vincenzo Conte, Alberto Panerai, Paola Sacerdote Silvia Franchi
Journal of Neuroinflammation, 16 (1) 17 April 2019, Article number 89 (2019)

Indole derivatives as multifunctional drugs: synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones
Monica Demurtas, Anna Baldisserotto, Ilaria Lampronti, Davide Moi, Gianfranco Balboni, Salvatore Pacifico, Silvia Verturani, Stefano Manfredini, Valentina Onnis
Bioorganic Chemistry, 85, 568-576 (2019)

Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors.
Deplano A, Cipriano M, Moraca F, Novellino E, Catalanotti B, Fowler CJ, Onnis V.
Journal of Enzyme Inhibition and Medicinal Chemistry, 34(1):562-576 (2019)

Benzofuran hydrazones as potential scaffold in the development of multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity.
Anna Baldisserotto, Monica Demurtas, Ilaria Lampronti, Davide Moi, Gianfranco Balboni, Silvia Vertuani, Stefano Manfredini, Valentina Onnis
European Journal of Medicinal Chemistry, 156, 118-125 (2018)

Synthesis and biological evaluation of novel pyrazoline-based aromatic sulfamates with potent carbonic anhydrase isoforms II, IV and IX inhibitory efficacy
Alessio Nocentini, Davide Moi, Gianfranco Balboni, Severo Salvadori, Valentina Onnis, Claudiu T. Supuran.
Bioorganic Chemistry, 77, 633-639 (2018)

Discovery of thiazolin-4-one-based aromatic sulfamates as a new class of carbonic anhydrase isoforms I, II, IV, and IX inhibitors
Alessio Nocentini, Davide Moi, Gianfranco Balboni, Valentina Onnis, Claudiu T. Supuran.
Bioorganic Chemistry, 77, 293-299 (2018).

Antagonism of EG-VEGF receptors is a novel targeted therapy for choriocarcinoma progression: in vitro, in vivo and clinical studies. Clin Cancer Res. 2017 Sep 12. pii: clincanres.0811.2017. Wael Traboulsi, Frederic Sergent, Houssine Boufettal, Sophie Brouillet, Rima Slim, Pascale Hoffmann, Mohammed Benlahfid, qun Zhou, Giafranco Balboni, Valentina Onnis, Pierre Bolze, Aude Salomon, Philippe Sauthier, François Mallet, Touria Aboussaouira, Jean-Jacques Feige, Mohamed Benharouga, Nadia Alfaidy.

Design, synthesis and antiviral evaluation of novel heteroarylcarbothioamide derivatives as dual inhibitors of HIV-1 Reverse transcriptase-associated RNase H and RDDP functions. Pathogen and Diseases Aug 31;75(6). doi: 10.1093/femspd/ftx078 (2017) Angela Corona, Valentina Onnis, Alessandro Deplano, Giulia Bianco, Monica Demurtas, Simona Distinto, Yung-Chi Cheng, Stefano Alcaro, Francesca Esposito, Enzo Tramontano

Novel propanamides as fatty acid amide hydrolase inhibitors European Journal of Medicinal Chemistry, 136 (2017) 523-542. A. Deplano, C. M. Morgillo, M. Demurtas, E. Björklund, M. Cipriano, M. Svensson, S. Hashemian, G. Smaldone, E. Pedone, F. J. Luque, M. G. Cabiddu, E. Novellino, C. J. Fowler, B. Catalanotti, V. Onnis

3,4-Dihydroquinazoline derivatives inhibit the activities of cholinesterase enzymes. Bioorganic  Medicinal Chemistry. 2017, 27, 1179-1185. Park B, Nam JH, Kim HJ, Onnis V, Balboni G, Lee K-T, Park JH, Catto M, Carotti A, Lee JY

Potent Nematicidal Activity of Maleimide Derivatives on Meloidogyne incognita. J Agric Food Chem. 2016, 64(24) 4876-4881. Eloh K, Demurtas M, Mura MG, Deplano A, Onnis V, Sasanelli N, Maxia A,  Caboni P.

Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones. Molecules. 2016 Apr 30;21(5). pii: E579. Onnis V, Demurtas M, Deplano A, Balboni G, Baldisserotto A, Manfredini S, Pacifico S, Liekens S, Balzarini J.

Antagonism of the Prokineticin System Prevents and Reverses Allodynia and Inflammation in a Mouse Model of Diabetes. PLoS ONE 2016; Jan 05; 11(1):e0146259. doi: 10.1371/journal.pone.0146259. Mara Castelli, Giada Amodeo, Lucia Negri, Roberta Lattanzi, Daniela Maftei, Cecilia Gotti, Francesco Pistillo, Valentina Onnis, Cenzo Congiu, Alberto E. Panerai, Paola Sacerdote, Silvia Franchi

Effect of the T-type channel blocker KYS-05090S in mouse models of acute and neuropathic pain. Pflügers Archiv – European Journal of Physiology 2016 Feb;468(2):193-9 PMID: 26354962 Said M’Dahoma, Vinicius M Gadotti, Fang-Xiong Zhang, Byeongyeon Park, Ji Hye Nam, Valentina Onnis, Gianfranco Balboni, Jae Yeol Lee, Gerald W Zamponi

Interaction of the N-(3-Methylpyridin-2-yl)amide Derivatives of Flurbiprofen and Ibuprofen with FAAH: Enantiomeric Selectivity and Binding Mode. PLoS One. 2015 Nov 13;10(11):e0142711. doi: 10.1371/journal.pone.0142711. Karlsson J, Morgillo CM, Deplano A, Smaldone G, Pedone E, Luque FJ, Svensson M, Novellino E, Congiu C, Onnis V, Catalanotti B, Fowler CJ.

In Vitro Nematicidal Activity of Aryl Hydrazones and Comparative GC-MS Metabolomics Analysis. J Agric Food Chem. 2015 18;63(45):9970-6. Eloh K, Demurtas M, Deplano A, Ngoutane Mfopa A, Murgia A, Maxia A, Onnis V, Caboni P.

Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor PLoS ONE (2015) 10(9): e0139212. doi:10.1371/journal.pone.0139212 Sandra Gouveia-Figueira, Jessica Karlsson, Alessandro Deplano, Sanaz Hashemian, Mona Svensson, Marcus Fredriksson Sundbom, Cenzo Congiu, Valentina Onnis, Christopher J. Fowler

Critical role for prokineticin 2 in CNS autoimmunity. Neurol Neuroimmunol Neuroinflamm. 2015 Apr 9;2(3):e95. doi: 10.1212/NXI.0000000000000095. eCollection 2015 Jun. Abou-Hamdan M, Costanza M, Fontana E, Di Dario M, Musio S, Congiu C, Onnis V, Lattanzi R, Radaelli M, Martinelli V, Salvadori S, Negri L, Poliani PL, Farina C, Balboni G, Steinman L, Pedotti R.

TRPV1 modulators: Synthesis and in vitro evaluation of 1-heteroaryl piperidinecarboxamide and piperazinylurea derivatives. Eur J Med Chem. 2015 Jul 15;100:129-38. doi: 10.1016/j.ejmech.2015.05.041. Epub 2015 Jun 6. Congiu C, Onnis V, Balboni G, Schiano-Moriello A, Di Marzo V, De Petrocellis L.

PPARγcontrols pregnancy outcome through activation of EG-VEGF: New insights into the mechanism of placental development. Am J Physiol Endocrinol Metab. 2015 Aug 15;309(4):E357-69. doi: 10.1152/ajpendo.00093.2015. Garnier V, Traboulsi W, Salomon A, Brouillet S, Fournier T, Winkler C, Desvergne B, Hoffmann P, Zhou QY, Congiu C, Onnis V, Benharouga M, Feige JJ, Alfaidy N.

Nematicidal activity of acetophenones and chalcones against Meloidogyne incognita and structure-activity considerations. Pest Manag Sci. 2015 Jan 16. doi: 10.1002/ps.3978. Caboni P, Aissani N, Demurtas M, Ntalli N, ONNIS V.

Inhibitory effect of positively charged triazine antagonists of prokinecitin receptors on the transient receptor vanilloid type-1 (TRPV1) channel. Pharmacol Res. 2015 Jul 17;99:362-369. doi: 10.1016/j.phrs.2015.07.009. Petrocellis L, Moriello AS, Byun JS, Sohn JM, Lee JY, Vázquez-Romero A, Garrido M, Messeguer A, Zhang FX, Zamponi GW, Deplano A, Congiu C, Onnis V, Balboni G, Marzo VD.

Synthesis and carbonic anhydrase I, II, IX and XII inhibitory activity of sulfamates incorporating piperazinyl-ureido moieties Bioorganic & Medicinal Chemistry 2015, 23(17):5619-25. doi:10.1016/j.bmc.2015.07.024 Cenzo Congiu, Valentina Onnis, Alessandro Deplano, Gianfranco Balboni, Mariangela Ceruso, Claudiu T. Supuran

Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity. Cenzo Congiu, Valentina Onnis, Alessandro Deplano, Gianfranco Balboni, Nurcan Dedeoglu,  Claudiu T. Supuran  Bioorganic & Medicinal Chemistry 2015, 15;25(18):3850-3. doi: 10.1016/j.bmcl.2015.07.060.

Effect of the T-type channel blocker KYS-05090S in mouse models of acute and neuropathic pain. Pflügers Archiv – European Journal of Physiology (2015)  Said M’Dahoma, Vinicius M Gadotti, Fang-Xiong Zhang, Byeongyeon Park, Ji Hye Nam, Valentina Onnis, Gianfranco Balboni, Jae Yeol Lee, Gerald W Zamponi

A New Convenient Synthetic Method and Preliminary Pharmacological Characterization of Triazinediones as Prokineticin Receptor Antagonists. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 81, p. 334-340(2014). Congiu C, ONNIS V, Deplano A, Salvadori S, Marconi V, Maftei D, Negri L, Lattanzi R, Balboni G .

Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β Species. CHEMICAL SCIENCE, vol. 5, p. 4851-4862 (2014).  A. S. DeToma, J. Krishnamoorthy, Y. Nam, H. J. Lee, J. R. Brender, A. Kochi, D. Lee, ONNIS V, C. Congiu, S. Manfredini, S. Vertuani, G. Balboni, A. Ramamoorthy, M. H. Lim

Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulfanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)- one/thione moieties.  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 24, p. 1176-1179 (2014). Congiu C, ONNIS V, Balboni G, Supuran CT

HALOGENATED TRIAZINEDIONES BEHAVE AS ANTAGONIST OF PKR1. IN-VITRO AND IN-VIVO PHARMACOLOGICAL CHARACTERIZATION. INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH (PRINT), vol. 5, p. 5064-5072 (2014). Lattanzi R., Congiu C., ONNIS V, Deplano A., Salvadori S., Marconi V., Maftei D., Francioso A., Ambrosio C., Casella I, Costa T., Caltabiano G., Matsoukas M.T., Balboni G, Negri L.

Inhibition of fatty acid amide hydrolase and cyclooxygenase by the N-(3-methylpyridin- 2-yl)amide derivatives of flurbiprofen and naproxen. EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 720, p. 383-390(2013). Cipriano M., Björklund E., Wilson A.A., Congiu C., ONNIS V, Fowler C.J.

Synthesis and biological evaluation of novel acylhydrazone derivatives as potential antitumor agents. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, p. 6592-6599 (2013).  CONGIU C., ONNIS V.

Inhibitory properties of ibuprofen and its amide analogues towards the hydrolysis and cyclooxygenation of the endocannabinoid anandamide. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2012 Jan 6. Fowler C.J., Björklund E., Lichtman A. H., Naidu P.S., Cenzo Congiu C., ONNIS V

Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context.  TOXICOLOGY, 297, 26- 33 (2012) Wall R.J., He G., Denison M.S., Congiu C., ONNIS V, Fernandes A.,Bell D.R., Rose M., Rowlands J. C., Balboni G., Mellor I.R.

Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins   Bioorg. Med. Chem. Lett. 22 (9), 3056-3062 (2012). Gianfranco Balboni, Cenzo Congiu, Valentina Onnis, Alfonso Maresca, Andrea Scozzafava, Jean-Yves Winum, Annalisa Maietti, Claudiu T. Supuran

Prokineticin Receptor 1 Antagonist PC-10 as a Biomarker for Imaging Inflammatory Pain. J. Nucl. Med. 52, 600-607 (2011). Jacobson O, Weiss ID, Niu G, Balboni G, Congiu C, Onnis V, Kiesewetter DO, Lattanzi R, Salvadori S, Chen X.

Synthesis and in vitro antitumor activity of new 4,5-dihydropyrazole derivatives. Bioorg. Med. Chem. 18, 6238-6248 (2010) Cenzo Congiu, Valentina Onnis, Loredana Vesci, Massimo Castorina, Claudio Pisano

Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors. J. Med. Chem. 53, 2286-2298 (2010) Valentina Onnis; Cenzo Congiu; Emmelie Björklund; Franziska Hempel; Emma Söderström; Chris J. Fowler

Synthesis and Evaluation of Anticancer Activity of 2-Arylamino-6-trifluoromethyl- 3-(hydrazonocarbonyl)pyridines. Bioorg. Med. Chem. 17, 6158-6165 (2009) Valentina Onnis, Maria Teresa Cocco, Roberta Fadda, Cenzo Congiu

The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1.  British Journal of Pharmacology 156, 412-419 (2009) C.J. Fowler, P.S. Naidu, A Lichtman, V. Onnis

2-Acylhydrazino-5-arylpyrrole derivatives: Synthesis and antifungal activity evaluation. Eur. J. Med. Chem. 44, 1288-1295 (2009)  Valentina Onnis, Alessandro De Logu, Maria Teresa Cocco, Roberta Fadda, Rita Meleddu, Cenzo Congiu

Synthesis and evaluation of antitumoral activity of ester and amide derivatives of 2-arylamino-6-trifluoromethyl-3-pyridinecarboxylic acids. Bioorg. Med. Chem. 16 (5), 2367-2378 (2008) Valentina Onnis, Valentina Lilliu, Maria Teresa Cocco, Cenzo Congiu

Design, synthesis, and in vitro antitumor activity of new 1,4-diarylimidazole-2-ones and their 2-thione analogues. Bioorg. Med. Chem. Lett. 18 (3), 989-993 (2008) Cenzo Congiu, Maria Teresa Cocco, Valentina Onnis

Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin. European Journal of Pharmacology, 565 (1-3), 26-36 (2007). Holt S., Paylor B., Boldrup L., Alajakku K., Vandevoorde S., Sundstrom A., Cocco M.T., Onnis V., Fowler C.J.

Further Studies on the Effect of Lysine at the C-Terminus of the Dmt-Tic Opioid Pharmacophore. Bioorg. Med. Chem., 15 (9), 3143-3151 (2007). Gianfranco Balboni, Valentina Onnis, Cenzo Congiu, Margherita Zotti, Yusuke Sasaki, Akihiro Ambo, Sharon D. Bryant, Yunden Jinsmaa, Lawrence H. Lazarus, Claudio Trapella, Ilaria Lazzari, Severo Salvadori

Synthesis and in vitro antitumoral activity of new 3,5-dicyanopyridine derivatives. Bioorg. Med. Chem., 15 (4), 1859-1867 (2007). Maria T. Cocco, Cenzo Congiu, Valentina Lilliu, Valentina Onnis

Effect of Lysine at C-Terminus of the Dmt-Tic Opioid Pharmacophore. J. Med. Chem. 49 (18), 5610 – 5617 (2006) Gianfranco Balboni, Valentina Onnis, Cenzo Congiu, Margherita Zotti, Yusuke Sasaki, Akihiro Ambo, Sharon D. Bryant, Yunden Jinsmaa, Lawrence H. Lazarus, Claudio Trapella, Severo Salvadori

Synthesis and In Vitro Antitumoral Activity of New Hydrazinopyrimidine-5-carbonitrile Derivatives. Bioorg. Med. Chem., 14 (2), 366-372 (2006). Maria T. Cocco, Cenzo Congiu, Valentina Lilliu, Valentina Onnis

New Potential Anticancer Agents Based on the Anthranilic Acid Scaffold. Synthesis and Evaluation of Biological Activity.    J. Med. Chem. 48 (26), 8245-8252 (2005). Cenzo Congiu, Maria T. Cocco, Valentina Lilliu, Valentina Onnis

Synthesis and antiproliferative activity of 2,6-Dibenzylamino-3,5-dicyanopyridines on human cancer cell lines. Eur. J. Med. Chem., 40 (12), 1365-1372 (2005). Maria T. Cocco, Cenzo Congiu, Valentina Lilliu, Valentina Onnis

In vitro antimycobacterial activity of newly synthesised S-alkylisothiosemicarbazone derivatives and synergistic interactions in combination with rifamycins against   Mycobacterium avium . International Journal of Antimicrobial Agents 26 (1), 28-32 (2005) A. De Logu, M. Saddi, Valentina Onnis, C. Sanna, C. Congiu, R. Borgna, M.T. Cocco

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