Pubblicazioni

 

Pubblicazioni

Lista delle Pubblicazioni più recenti (2005-2019):

MOSCHETTI G,AMODEO G, MAFTEI D, LATTANZI R, PROCACCI P, SARTORI P, BALBONI G, ONNIS V, CONTE V, PANERAI A, SACERDOTE P, FRANCHI S. (2019) Targeting prokineticin system counteracts hypersensitivity, neuroinflammation, and tissue damage in a mouse model of bortezomib-induced peripheral neuropaty. J. NEUROINFLAMMATION Vol. 16, art. numb. 89.

DEMURTAS M, BALDISSEROTTO A, LAMPRONTI I, MOI D, BALBONI G, PACIFICO S, VERTUANI S, MANFREDINI S, ONNIS V. (2019) Indole derivatives as multifunctional drugs: synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity of indole hydrazones. BIOORG. CHEM. Vol. 85, p. 568-576.

POLO S, DIAZ AF, GALLARDOU N, LEANEZ S, BALBONI G, POL O. (2019) Treatment with the delta opioid agonist UFP-512 alleviates chronic inflammatory and neuropathic pain: mechanisms implicated. FRONT PHARMACOL. Vol. 10, art. numb: 283.

XU Y, ZHI F, PENG Y, SHAO N, KHIATI D, BALBONI G, YANG Y, XIA Y. (2019) d-Opioid receptor activation attenuates hypoxia/MPP+-induced downregulation of PINK1: a novel mechanism of neuroprotection against parkinson injury. MOL. NEUROBIOL. Vol. 56, p. 252-266.

BALDISSEROTTO A, DEMURTAS M, LAMPRONTI I, MOI D, BALBONI G, VERTUANI S, MANFREDINI S, ONNIS V. (2018) Benzofuran hydrazones as potential scaffold in the development of multifunctional drugs: Synthesis and evaluation of antioxidant, photoprotective and antiproliferative activity. EUR. J. MED. CHEM. Vol. 156, p. 118-125.

NOCENTINI A, MOI D, BALBONI G, SALVADORI S, ONNIS V, SUPURAN CT. (2018) Synthesis and biological evaluation of novel pyrazoline-based aromatic sulfamates with potent carbonic anhydrase isoforms II, IV and IX inhibitory efficacy.  BIOORG. CHEM. vol. 77, p. 633-639.

NOCENTINI A, MOI D, BALBONI G, ONNIS V, SUPURAN CT. (2018) Discovery of thiazolin-4-one-based aromatic sulfamates as a new class of carbonic anhydrase isoforms I, II, IV and IX inhibitors. BIOORG. CHEM. vol.77, p.293-299.

TRABOULSI W, SERGENT F, BOUFETTAL H, BROUILLET S, SLIM R, HOFFMANN P, BENLAHFID M, ZHOU QY, BALBONI G, ONNIS V, BOLZE PA, SALOMON A, SAUTHIER P, MALLET F, ABOUSSAOUIRA T, FEIGE JJ, BENHAROUGA M, ALFAIDY N. (2017) Antagonism of EG-VEGF receptors as targeted therapy for choriocarcinoma progression in vitro and in vivo. CLIN. CANCER RES. vol. 23, p. 7130-7140.

KANG MG, PARK J, BALBONI G, LIM MH, LEE C, RHEE HW. (2017) Genetically encodable bacterial flavin transferase for fluorogenic protein modification in mammalian cells. ACS SYNTH BIOL. vol. 6, p. 667-677.

PARK B, NAM JH, KIM JH, KIM HJ, ONNIS V, BALBONI G, LEE KT, PARK JH, CATTO M, CAROTTI A, LEE JY. (2017) 3,4-Dihydroquinazoline derivatives inhibit the activities of cholinesterase enzymes. BIOORG. MED. CHEM. LETT., vol. 27, p. 1179-1185.

CAIOLI S, SEVERINI C, CIOTTI T, FLORENZANO F, PIMPINELLA D, PETROCCHI PASSERI P, BALBONI G, POLISCA P, LATTANZI R, NISTICO’ R, NEGRI L, ZONA C. (2017) Prokineticin system modulation as a new target to counteract the amyloid beta toxicity induced by glutamatergic alterations in an in vitro model of Alzheimer’s disease. NEUROPHARMACOLOGY, vol. 116, p. 82-97.

CHAO D, WANG Q, BALBONI G, DING G, XIA Y. (2016) Attenuating ischemic disruption of K+ homeostasis in the cortex of hypoxic-ischemic neonatal rats: DOR activation vs. acupuntare treatment. MOL. NEUROBIOL., vol. 53, p. 7213-7227.

LANDUCCI E, LATTANZI R, GERACE E, SCARTABELLI T, BALBONI G, NEGRI L, PELLEGRINI-GIAMPIETRO DE. (2016) Prokineticins are neuroprotective in models of cerebral ischemia and ischemic tolerance in vitro. NEUROPHARMACOLOGY, vol. 108, p. 39-48.

ONNIS V, DEMURTAS M, DEPLANO A, BALBONI G, BALDISSEROTTO A, MANFREDINI S, PACIFICO S, LIEKENS S, BALZARINI J. (2016) Design, synthesis and evaluation of antiproliferative activity of new benzimidazolehydrazones. MOLECULES, vol. 21, pii: E579.

M’DAHOMA S, GADOTTI VM, ZHANG FX, PARK B, NAM JH, ONNIS V, BALBONI G, LEE JY, ZAMPONI G. (2016) Effect of the T-type channel blocker KYS-05090S in mouse models of acute and neuropathic pain. PFLUGERS ARCH., vol. 468, p. 193-199.

SAKAKIBARA N, BALBONI G, CONGIU C, ONNIS V, DEMIZU Y, MISAWA T, KURIHARA M, KATO Y, MARUYAMA T, TOYAMA M, OKAMOTO M, BABA M. (2015) Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives. ANTIVIR. CHEM. CHEMOTHER., vol. 24, p. 62-71.

SEVERINI C, LATTANZI R, MAFTEI D, MARCONI V, CIOTTI MT, PETROCCHI PASSERINI P, FLORENZANO F, DEL DUCA E, CAIOLI S, ZONA C, BALBONI G, SALVADORI S, NISTICÒ R, NEGRI L. (2015) Bv8/Prokineticin 2 is involved in Abeta-induced neurotoxicity. SCIENTIFIC REPORTS, vol. 5, article number 15301.

CONGIU C, ONNIS V, DEPLANO A, BALBONI G, CERUSO M, SUPURAN CT. (2015) Synthesis and carbonic anhydrase I, II, IX AND XII inhibitory activity of sulfamates incorporating piperazinyl-ureido moieties. BIOORG. MED. CHEM., vol. 23, p. 5619-5625.

CONGIU C, ONNIS V, DEPLANO A, BALBONI G, DEDEOGLU N, SUPURAN CT. (2015) Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase i, II, IX and XII inhibitory activity. BIOORG. MED. CHEM. LETT., vol. 25, p.3850-3853.

DE PETROCELLIS L, SCHIANO-MORIELLO A, BYUN JS, SOHN JM, LEE JY, VAZQUEZ-ROMERO A, GARRIDO M, MESSEGUER A, ZHANG F-X, ZAMPONI GW, DEPLANO A, CONGIU C, ONNIS V, BALBONI G, DI MARZO V. (2015) Inhibitory effect of positively charged triazine antagonists of prokineticin receptors on the transient vanilloid type-1 (TRPV1) channel. PHARMACOLOGICAL RESEARCH, vol. 99, p. 362-369.

CONGIU C, ONNIS V, BALBONI G, SCHIANO-MORIELLO A, DI MARZO V, DE PETROCELLIS L. (2015) TRPV1 modulators: Synthesis and in vitro evaluation of 1-heteroarylpiperidinecarboxamide and piperazinylurea derivatives. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.100, p. 129-138.

ABOU-HAMDAN M, COSTANZA M, FONTANA E, DI DARIO M, MUSIO S, CONGIU C, ONNIS V, LATTANZI R, RADAELLI M, MARTINELLI V, SALVADORI S, NEGRI L, POLIANI PL, FARINA C, BALBONI G, STEINMAN L, PEDOTTI R. (2015) Critical role for prokineticin 2 in CNS autoimmunity. NEUROLOGY® NEUROIMMUNOLOGY & NEUROINFLAMMATION, vol. 2, p. e95.

CAO S; CHAO D; ZHOU H; BALBONI G; XIA Y. (2015) A novel mechanism for cytoprotection against hypoxic injury: delta-opioid receptor-mediated increase in Nrf2 translocation. BR. J. PHARMACOL.vol. 172, p. 1869-1881.

LATTANZI R; MAFTEI D; MARCONI V; FLORENZANO F; FRANCHI S; BORSANI E; RODELLA LF; BALBONI G; SALVADORI S; SACERDOTE P; NEGRI L. (2015) Prokineticin 2 upregulation in the peripheral nervous system has a major role in triggering and maintaining neuropathic pain in the chronic constriction injury model. BIOMED RESEARCH INTERNATIONAL, vol. 2015, article ID 301292.

GUIDA F; LATTANZI R; BOCCELLA S; MAFTEI D; ROMANO R; MARCONI V; BALBONI G; SALVADORI S; SCAFURO MA; DE NOVELLIS V; NEGRI L; MAIONE S; LUONGO L. (2015) PC1, a non-peptide PKR1-preferring antagonist, reduces pain behavior and spinal neuronal sensitization in neuropathic mice. PHARMACOLOGICAL RESEARCH, vol. 91, p. 36-46.

LIANG J; CHAO D; SANDHU HK; YU Y; ZHANG L; BALBONI G; KIM DH; XIA Y. (2014) Delta-opioid receptors up-regulate excitatory amino acid transporter in mouse astrocytes. BRITISH JOURNAL PHARMACOLOGY, vol. 171, p. 5417-5430.

LATTANZI R; CONGIU C; ONNIS V; DEPLANO A; SALVADORI S; MARCONI V; MAFTEI D; FRANCIOSO A; AMBROSIO C; CASELLA I; COSTA T; CALTABIANO G; MATSOUKAS MT; BALBONI G; NEGRI L. (2014) Halogenated trizinediones behave as antagonists of PKR1: in-vitro and in-vivo pharmacological characterization. INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, vol. 5, p. 5064-5072.

DE TOMA AS; KRISHNAMOORTHY J; NAM Y; JIN LEE H; BRENDER JR; KOCHI A; LEE D; ONNIS V; CONGIU C; MANFREDINI S; VERTUANI S; BALBONI G; RAMAMOORTHY A; LIM MH. (2014) Interaction and reactivity of synthetic aminoisoflavones with metal-free and metal-associated amyloid-beta. CHEMICAL SCIENCE, vol. 5 p. 4851-4862.

MAFTEI D; MANCONI V; FLORENZANO F; GIANCOTTI LA; CASTELLI M; MORETTI S; BORSANI E; RODELLA LF; BALBONI G; LUONGO L; MAIONE S; SACERDOTE P; NEGRI L; LATTANZI R. (2014) Controlling the activation of the Bv8/prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals. BRITISH JOURNAL OF PHARMACOLOGY, vol. 171, p. 4850-4865.

KABLI N; NGUYEN T; BALBONI G; O’DOWD BF; GEORGE SR. (2014) Antidepressant-like and anxiolytic-like effects following activation of the mu-delta opioid receptor heteromer in the nucleus accumbens. MOLECULAR PSYCHIATRY, vol. 19, p, 986-994.

CONGIU C; ONNIS V; DEPLANO A; SALVADORI S; MARCONI V; MAFTEI D; NEGRI L; LATTANZI R; BALBONI G. (2014) A new convenient synthetic method and preliminary pharmacological characterization of triazinediones as prokineticin receptor antagonists. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 81, p. 334-340.

CONGIU C; ONNIS V; BALBONI G; SUPURAN CT (2014) Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)-one/thione moieties. BIOORGANIC & MEDICINAL
CHEMISTRY LETTERS, vol. 24, p. 1776-1779.

CHARFI I; NAGI K; MNIE-FILALI O; THIBAULT D; BALBONI G; SCHILLER PW; TRUDEAU LE; PINEYRO G. Ligand- and cell-dependent determinants of internalization and cAMP modulation by delta opioid receptor (DOR) agonists. (2014) CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 71, p. 1529-1546.

HE X, YANG Y, ZHI F, MOORE ML, KANG X, CHAO D, WANG R, BALBONI G, SALVADORI S, KIM DH, XIA Y. (2013) Delta-opioid receptor activation modified microRNA expression in the rat kidney under prolonged hypoxia. PLOS ONE, vol. 8, e61080.

LESMA G, SALVADORI S, AIRAGHI F, BOJNIK E, BORSODI A, RECCA T, SACCHETTI A, BALBONI G, SILVANI A. (2013) Synthesis, pharmacological evaluation and conformational investigation of endomorphin-2 hybrid analogues. MOLECULAR DIVERSITY, vol. 17, p. 19-31.

CRICHARD-LALONDE M, NAGI K, AUDET N, SLENO R, AMRAEI M, HOGUE M, BALBONI G, SCHILLER P W, BOUVIER M, HÉBERT T E, PINEYRO G. (2013) Conformational dynamics of KIR3.1/KIR3.2 channel activation via delta-opioid receptors. MOLECULAR PHARMACOLOGY, vol. 83, p. 416-428.

CHAO D, HE X, YANG Y, BALBONI G, SALVADORI S, KIM DH, XIA Y. (2012) Hydrogen sulfide induced disruption of Na+ homeostasis in the cortex. TOXICOLOGICAL SCIENCES, vol. 128, p. 198-208.

CHAO D, HE X, YANG Y, BAZZY-ASAAD A, LAZARUS LH, BALBONI G, KIM DH, XIA Y. (2012) DOR activation inhibits anoxic/ischemic Na+ influx through Na+ channels via PKC mechanisms in the cortex. EXPERIMENTAL NEUROLOGY. vol 236; p. 228-239.

WALL R J, HE G, DENISON M S, CONGIU C, ONNIS V, FERNANDES A, BELL D R, ROSE M, CRAIG ROWLANDS J, BALBONI G, MELLOR I R. (2012) Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context. TOXICOLOGY. vol. 297; p. 26-33.

BALBONI G, CONGIU C, ONNIS V, MARESCA A, SCOZZAFAVA A, WINUM J-Y, MAIETTI A, SUPURAN CT. (2012) Flavones and structurally related 4-chromenones inhibit carbonic anhydrases by a different mechanism of action compared to coumarins.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. vol. 22; p. 3063-3066.

JACOBSON O, WEISS ID, NIU G, BALBONI G, CONGIU C, ONNIS V, KIESEWETTER DO, LATTANZI R, SALVADORI S, CHEN X. (2011) Prokineticin receptor 1 antagonist PC-10 as a biomarker for imaging inflammatory pain. THE JOURNAL OF NUCLEAR MEDICINE. vol. 52; p. 600-607.

BALBONI G, SALVADORI S, MARCZAK  E. D, KNAPP J. M, LAZARUS L. H, PENG X, SI Y. G, NEUMEYER J. L. (2011) Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. vol. 46; p. 799-803.

KABLI N, MARTIN N, FAN T, NGUYEN T, HASBI A, BALBONI G, O’DOWD BF, GEORGE SR. (2010) Agonists at the delta-opioid receptor modify the binding of mu-receptor agonists to the mu-delta receptor hetero-oligomer. BRITISH JOURNAL OF PHARMACOLOGY. vol. 161; p. 1122-1136.

BALBONI G, MARZOLA E, SASAKI Y, AMBO A, MARCZAK E. D, LAZARUS L. H, SALVADORI S. (2010) Role of 2′,6′-dimethyl-L-tyrosine (Dmt) in some opioid lead compounds. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 18; p. 6024-6030.

BALLET S, MARCZAK E D, FEYTENS D, SALVADORI S, SASAKI Y, ABELL A. D, LAZARUS L. H, BALBONI G., TOURWE’ D. (2010) Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20; p. 1610-1613.

BALBONI G., SALVADORI S., TRAPELLA C., KNAPP B. I., BIDLACK J. M., LAZARUS L. H., PENG X., NEUMEYER J. L. (2010) Evolution of the bifunctional lead mu agonist / delta antagonist containing the 2′,6′-dimethyl-L-tyrosine-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Dmt-Tic) opioid pharmacophore. ACS CHEMICAL NEUROSCIENCE, vol. 1; p. 155-164.

KANG X, CHAO D, GU Q, DING G, WANG Y, BALBONI G., LAZARUS L. H, XIA Y (2009). Delta-opioid receptors protect from anoxic disruption of Na+ homeostasis via Na+ channel regulation. CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 66; p. 3505-3516.

BALBONI G., TRAPELLA C, SASAKI Y, AMBO A, MARCZAK E. D, LAZARUS L. H, SALVADORI S . (2009) Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore. JOURNAL OF MEDICINAL CHEMISTRY, vol. 52; pp. 5556-5559.

GIANNINI E, LATTANZI R, NICOTRA A, CAMPESE A. F, GRAZIOLI P, SCREPANTI I, BALBONI G., SALVADORI S, SACERDOTE P, NEGRI L. (2009) The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA vol. 106; pp. 14646-14651.

MARCZAK E.D., JINSMAA Y., MYERS P.H., BLANKENSHIP T., WILSON R., BALBONI G., SALVADORI S., LAZARUS L. H. (2009) Orally administered H-Dmt-Tic-Lys-NH-CH2-Ph (MZ-2), a potent mu/delta-opioid receptor antagonist, regulates obese-related factors in mice. EUR. J. PHARMACOL. vol. 616, pp. 115-121.

CHAO D, BALBONI G., LAZARUS L. H, SALVADORI S, XIA Y. (2009). Na+ mechanism of delta-opioid receptor induced protection from K+ leakage in the cortex. CELLULAR AND MOLECULAR LIFE SCIENCES. vol. 66, pp. 1105-1115.

KANG XUE-ZHI, GU QUAN-BAO, DING GUANG-HONG, CHAO DONG-MAN, WANG YING-WEI, BALBONI G., LAZARUS L. H, XIA YING. (2008). Delta-opioid receptor induced inhibition of sodium channel function. JOURNAL OF ACUPUNCTURE AND TUINA SCIENCE. vol. 6, pp. 276-278.

BALLET S, FEYTENS D, DE WACHTER R, DE VLAEMINCK M, MARCZAK E. D, SALVADORI S, DE GRAAF C, ROGNAN D, NEGRI L, LATTANZI R, LAZARUS L. H, TOURWE’ D, BALBONI G. (2009). Conformationally constrained opioid ligands: the Dmt-Aba and Dmt-Aia versus Dmt-Tic scaffold. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. vol. 19, pp. 433-437 .

BALBONI G., LAZZARI I, TRAPELLA C, NEGRI L, LATTANZI R, GIANNINI E, NICOTRA A, MELCHIORRI P, VISENTIN S, DE NUCCIO C, SALVADORI S. (2008). Triazine compounds as antagonists at Bv8-prokineticin receptors. JOURNAL OF MEDICINAL CHEMISTRY. vol. 51, pp. 7635-7639 .

JINSMAA Y, MARCZAK E. D, BALBONI G., SALVADORI S, LAZARUS L. H. (2008). Inhibition of the development of morphine tolerance by a potent dual mu- / delta-opioid antagonist, H-Dmt-Tic-Lys-NH-CH2-Ph. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. vol. 90, pp. 651-657 .

CHAO D, BAZZY-ASAAD A, BALBONI G., SALVADORI S, XIA Y. (2008). Activation of DOR attenuates anoxic K+ derangement via inhibition of Na+ entry in mouse cortex. CEREBRAL CORTEX (on line). vol. 18, pp. 2217-2227.

BALBONI G., FIORINI S, BALDISSEROTTO A, TRAPELLA C, SASAKI Y, AMBO A, MARCZAK E. D, LAZARUS L. H, SALVADORI S. (2008). Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. JOURNAL OF MEDICINAL CHEMISTRY. vol. 51, pp. 5109-5117.

SALVADORI S, FIORINI S, TRAPELLA C, PORRECA F, DAVIS P, SASAKI Y, AMBO A, MARCZAK E D, LAZARUS L H, BALBONI G. (2008) Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH2-Bid (UFP-502). BIOORGANIC & MEDICINAL CHEMISTRY vol. 16, pp. 3032-3038.

RYU E K, WU Z, CHEN K, LAZARUS L H, MARCZAK E D, SASAKI Y, AMBO A, SALVADORI S, REN C, ZHAO H, BALBONI G, CHEN X. (2008) Synthesis of a potent and selective (18)F-labeled delta-opioid receptor antagonist derived from the Dmt-Tic pharmacophore for positron emission tomography imaging. JOURNAL OF MEDICINAL CHEMISTRY vol. 51, pp. 1817-1823.

VERGURA R, BALBONI G, SPAGNOLO B, GAVIOLI E, LAMBERT D. G, MADONALD J, TRAPELLA C, LAZARUS L. H, REGOLI D, GUERRINI R, SALVADORI S, CALO’ G. (2008) Anxiolytic- and antidepressant-like activities of H-Dmt-Tic-NH-CH(CH2-COOH)-Bid (UFP-512), a novel selective delta opioid receptor agonist. PEPTIDES vol. 29, pp. 93-103.

AGUILA B, COULBAULT L, BOULOUAERD M, LEVEILLE F, DAVIS A, TOTH G, BORSODI A, BALBONI G., SALVADORI S, JAUZAC P, ALLOUCHE S. (2007). In vitro and in vivo pharmacological profile of UFP-512, a novel selective delta-opioid receptor agonist, correlation between desensitization and tolerance. BRITISH JOURNAL OF PHARMACOLOGY. vol. 152, pp. 1312-1324.

BALBONI G., ONNIS V, CONGIU C, ZOTTI M, SASAKI Y, AMBO A, BRYANT S. D, JINSMAA Y, LAZARUS L. H, LAZZARI I, TRAPELLA C, SALVADORI S. (2007). Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore. BIOORGANIC & MEDICINAL CHEMISTRY. vol. 15, pp. 3143-3151.

CHAO D, BAZZY-ASAAD A, BALBONI G., XIA Y. (2007). Delta-, but not mu-, opioid receptor stabilize K+ homeostasis by reducing Ca2+ influx in the cortex during acute hypoxia. JOURNAL OF CELLULAR PHYSIOLOGY. vol. 212, pp. 60-67.

SALVADORI S, TRAPELLA C, FIORINI S, NEGRI L, LATTANZI R, BRYANT S. D, JINSMAA Y, LAZARUS L. H, BALBONI G. (2007). A new opioid designed multiple ligand derived from the mu opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic. BIOORGANIC & MEDICINAL CHEMISTRY. vol. 15, pp. 6876-6881.

BALBONI G., ONNIS V, CONGIU C, ZOTTI M, SASAKI Y, AMBO A, BRYANT S. D, JINSMAA Y, LAZARUS L. H, TRAPELLA C, SALVADORI S. (2006). Effect of Lysine at C-Terminus of the Dmt-Tic Opioid Pharmacophore. JOURNAL OF MEDICINAL CHEMISTRY. vol. 49, pp. 5610-5617.

BALLET S, SALVADORI S, TRAPELLA C, BRYANT S. D, JINSMAA Y, LAZARUS L. H, NEGRI L, GIANNINI E, LATTANZI R, TOURWE’ D, BALBONI G. (2006). New 2′,6′-Dimethyl-L-Tyrosine (Dmt) Opioid Peptidomimetics Based on the Aba-Gly Scaffold. Development of Unique mu-Opioid Ligands. JOURNAL OF MEDICINAL CHEMISTRY. vol. 49, pp. 3990-3993.

LAZARUS L. H., BRYANT S. D., SALVADORI S., GUERRINI R., BALBONI G., TSUDA Y., OKADA Y. (2006). Dimethyltyrosine, the Viagra of Opioids. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES. vol. 22, pp. 258-262.

NEUMEYER J. L, PENG X, KNAPP B. I, BIDLACK J. M, LAZARUS L. H, SALVADORI S, TRAPELLA C, BALBONI G. (2006). New Opioid Designed Multiple Ligand from Dmt-Tic and Morphinan Pharmacophores. JOURNAL OF MEDICINAL CHEMISTRY. vol. 49, pp. 5640-5643.

TORREGROSSA M. M, JUTKIEWICZ E. M, MOSBERG H. I, BALBONI G., WATSON S. J, WOODS J. H. (2006). Peptidic delta opioid receptor agonists produce antidepressant-like effects in the forced swim test amd regulate BDNF mRNA expression in rats. BRAIN RESEARCH. vol. 1069, pp. 172-181.

VAZQUEZ M. V, BLANCO J. B, SALVADORI S, TRAPELLA C, ARGAZZI R, BRYANT S. D, JINSMAA Y, LAZARUS L. H, NEGRI L, GIANNINI E, LATTANZI R, COLUCCI M, BALBONI G. (2006). 6-N,N-Dimethylamino-2,3-naphthalimide: A New Environment-Sensitive Fluorescent Probe in delta- and mu-Selective Opioid Peptides. JOURNAL OF MEDICINAL CHEMISTRY. vol. 49, pp. 3653-3658.

VERGURA R, VALENTI E, HEBBES C. P, GAVIOLI E. C, SPAGNOLO B, MCDONALD J, LAMBERT D. G, BALBONI G., SALVADORI S, REGOLI D, CALO’ G. (2006). Dmt-Tic-NH-CH2-Bid (UFP-502), a Potent DOP Receptor Agonist; In Vitro and in Vitro Studies. PEPTIDES. vol. 27, pp. 3322-3330.

BALBONI G., COCCO M. T., SALVADORI S., ROMAGNOLI R., SASAKI Y., OKADA Y., BRYANT S. D., JINSMAA Y., LAZARUS L. H. (2005). From the potent and selective mu opioid receptor agonist H-Dmt-D-Arg-Phe-Lys-NH2 to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH. JOURNAL OF MEDICINAL CHEMISTRY. vol. 48, pp. 5608-5611.

BALBONI G., GUERRINI R., SALVADORI S., NEGRI L., GIANNINI E., BRYANT S. D., JINSMAA Y., LAZARUS L. H. (2005). Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH2-Bid into delta-opioid antagonists by N1-benzimidazole alkylation. JOURNAL OF MEDICINAL CHEMISTRY. vol. 48, pp. 8112-8114.

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