A nominal registration fee of 250 € will be charged to offset administrative costs. Registration fees also cover accommodation and meals.
The submission deadline for all applications is
June 30th 2014.
Each applicant must submit the application form with personal data, education, professional experiences and an abstract for a short talk or a poster presentation. The Organizing Committee will review each application form and notify the applicant of their admission to the Summer School by July 30th . Accepted applicants will be required to complete their registration form not later than September 6.
Application forms can be visualized and downloaded here. Filled applications should be uploaded and submitted using the form below:
The Organizing Committee will review each registration form and notify the applicant of their admission to the Summer School by August 31 2014. Accepted applicants will be required to complete their registration form not later than September 6 2014.
In case of special needs please feel free to contact us at: email@example.com
September 28 – October 3, 2014
6.00 pm Registration
Enzo Tramontano Summer School welcoming remarks
Giorgio Palù President of the European Society for Virology welcoming remarks
Carlo Federico Perno Introduction to Inaugural Lecture
Jan Balzarini Carbohydrate binding agents: novel therapeutic concept as selective antiviral compounds.
8.30 pm Dinner
Chairman: Cristina Parolin
Stephan Becker Identifying targets for antifiloviral interventions
Maurizio Botta Design, synthesis and biological evaluation of human DDX3 inhibitors with multiple antiviral activities
11.00-11.15am Coffee break
Chairman: Stuart Le Grice
Eric Freed Development of potent and broadly active HIV-1 maturation inhibitors
Giorgio Palù Different approaches to develop effective antiviral strategies
1.00 pm Lunch
3.30-5.00 pm Discussion groups
5.00-6.00 pm Coffee break – Poster session I
Chairman: Elias Maccioni
Florencia Linero Isolation and characterization of Nanobodies against Junin virus as new and improved treatment option for Argentine hemorrhagic fever
Serena Massari Targeting Influenza A Virus RNA-dependent-RNA- polymerase: development of PA/PB1 interaction inhibitors
Finny Varghese Novel antivirals affecting Alphaviruses, including the re- emerging Chikungunya virus
Marta Cadeddu Identification and characterization of HERV-K (HML-10) in GRCh37/hg19 assembly and their possible association with the human diseases
Pouya Hassandavish Mechanism study of baicalein activity against dengue virus replication
8.00 pm Dinner
Chairman: Giorgio Palù
Le Grice Stuart Therapeutic Targeting of the Retroviral RNA Genome
Mátyus Péter Through hardships to the drug candidate (Per aspera ad astra) – old and new concepts in HIV drug discovery
11.00-11.15am Coffee Break
Chairman: Eric Freed
Thomas Mertens Mechanisms, clinical problems and management of resistance against herpesvirus infections
Birgitta Wöhrl Inhibition of Foamy Virus RNase H by HIV-1 RNase H inhibitors development of a model system
1.00 pm Lunch
3.30-5.00 pm Discussion groups
5.00-6.00 pm Coffee break – Poster session II
Chairman: Maurizio Botta
St. Patrick Reid The lipid kinase sphingosine kinase 2 is an essential host factor recruited by Chikungunya virus during infection
Agharbaoui Fatima E From natural products to HIV-1 IN/LEDGF interaction inhibitors:computational and synthetic approaches
Michele Celestino Unrevealing the molecular mechanisms accounting for the FIV envelope glycoprotein ability to overcome feline tetherin restriction
Valeria Cannas Identification of VP35 dsRNA binding pocket useful residues for development of small-molecules inhibitors against Ebola virus
Łukasz Świątek Antiviral activity of leaves and cones of Alnus sieboldiana Matsum against HHV-1
8.00 pm Dinner
Chairman: Jan Balzarini
Reuben Harris The Biological and Pathological Importance of Enzyme- Catalyzed DNA Cytosine Deamination
Federico Gago Structure-based computational strategies in the design of antiviral drugs
11.00-11.15am Coffee Break
Chairman: Thomas Mertens
Kvaratskhelia Mamuka Multimerization selective inhibitors of HIV-1 integrase
Enzo Tramontano Are human endogenous retroviruses possible drug targets?
1.00 pm Lunch
8.00 pm Dinner
Chairman: Stephan Becker
Ben Berkhout New anti-HIV approaches: peptide inhibitors, RNAi gene therapy and the humanized mouse model for drug testing
Maccioni Elias Drug design: principles and considerations
11.00-11.15am Coffee Break
Round table on “Working in a company after the PhD”
Chairman: Stuart Le Grice
Participant: Franco Lori and Vincenzo Summa
1.00 pm Lunch
3.00-4.30 pm Discussion groups
4.30-5.00 pm Coffee Break
Chairman: Reuben Harris
Roberto Di Santo Inhibiting the HIV Integration Process: Past, Present, and the Future
Camarasa María José gp120 as a target of the design and discovery of HIV- entry/fusion inhibitors
8.00 pm Social Dinner
Breakfast and leaving
JAN BALZARINI obtained his Master Degree in Engineer in Chemistry and Agriculture, Specialisation in Industrial Microbiology and Biochemistry, at Katholieke Universiteit Leuven, Belgium. In 1984 obtained hisPhD in Agricultural Sciences in Prof. Erik De Clercq Lab. From October 2001 is Full Professor (“Gewoon Hoogleraar”) at the Faculty of Medicine, and from 2006 is head of the Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.Member of the Grand Jury of the René Descartes-Prize of the European Commission. Honorary Visiting Professor at Cardiff University, School of Pharmacy (2011-2013). Visiting Professor at the University “Tor Vergata” at Rome, Italy (2004-2013). Cardiff University Distinguished Visiting Fellow 2009/2010 at the Welsh School of Pharmacy . Approximately 160 first-author, and more than 940 co-author papers in international peer-reviewed journals between 1980 and 2014. (Co)authored 16 book chapters, ~ 130 proceeding articles, and more than 500 published abstracts between 1980 and 2014. Among his scientific interests there are: chemotherapy of (retro)viral diseases with special emphasis on herpes virus infections (i.e. herpes simplex, varicella-zoster virus, cytomegalovirus), influenza virus and retrovirus infections (including AIDS); chemotherapy of malignant diseases, including combined gene/chemotherapy of cancer; molecular mechanisms of action and pharmacology of antiviral and antitumor compounds, in particular nucleoside and nucleotide analogues and carbohydrate-binding agents; Molecular mechanisms of antiviral and anticancer drug resistance; virus replication (i.e. DNA polymerase, reverse transcriptase) and virus entry as target of therapeutic intervention; prodrug technologies to improve the antiviral/cancer drug activity of (non)nucleoside analogues. He received numerous awards, including : Research (ISAR) (Laureat) “Carbohydrate-binding agents: a novel tool for the inhibition of enveloped viruses”, in 2011 Pharmacia-ASPET Award for Experimental Therapeutics-2011 of the American Society for Pharmacology and Experimental Therapeutics . “Discovery and development of novel concepts and drug leads for antiviral and anticancer chemotherapy”. He is holder of more than twenty approved and/or submitted patent applications of important antiretroviral drugs.
STEPHAN BECKER is the director of the Institute of Virology at the Philipps University Marburg. He studied Pharmaceutical Sciences and performed his PhD on energy metabolism of tumor cells. Then he moved to the Institute of Virology in Marburg where he started working with filoviruses, mainly on replication strategies of these highly pathogenic viruses. In 2006 he was appointed as a group leader at the Robert Koch Institut, Berlin before accepting a full professorship at the Philipps University, Marburg in 2008. He is speaker of the German research foundation funded collaborative research center 1021 “Sonderforschungsbereich 1021” and coordinates the section “Emerging Infections” of the German Center for Infection Research. Research interests are morphogenesis and pathogenicity of viruses causing hemorrhagic fevers. Viruses crossing the species barrier between animal and man (zoonotic viruses) represent a growing problem for our societies since the interfaces between animals and humans became more extended due to intensive land usage worldwide. In rare cases animal viruses can cause severe partially fatal diseases in the human host. Understanding the pathogenesis of those infections might provide new strategies to treat those diseases. A classic example for a viral zoonosis is Marburg virus, which jumps from bats to humans causing a hemorrhagic fever with high mortality. Basic mechanisms of how Marburg virus replicates in the host cell are still not understood and are in the focus of Stephan Becker`s research activities.
BEN BERKHOUT studied molecular biology at the Leiden University in the Netherlands and obtained his PhD in 1986 on a research project concerning the regulation of gene expression in RNA bacteriophages, in particular translational control by means of RNA structure. He performed postdoctoral research at the Dana Farber Cancer Institute of the Harvard Medical School in the field of molecular immunology and initiated HIV-1 research at the NIH in Bethesda. BB initiated a molecular virology research line in 1991 upon his return to the Netherlands and has been at the University of Amsterdam since then. He became Head of the Laboratory of Experimental Virology and was appointed Professor of Human Retrovirology. BB is editor for several journals (Retrovirology, Virus Research, RNA Biology, Journal of Biomedical Science) and associate editor for many more (NAR, JVI, JGV, JBC etc.). BB published over 410 peer-reviewed manuscripts on diverse topics concerning HIV-1 replication, virus evolution, virus discovery, new antiviral therapeutic strategies and HIV-1 vaccine design. He received the Retrovirology Prize 2008 for his pioneering research on the structure and function of the HIV-1 RNA genome. His work received >13,400 citations and he has an H-index of 61.
MAURIZIO BOTTA graduated with honors in chemistry from the University of Rome in 1974. After his military service he returned to work at the Institute of Organic Chemistry, University of Rome with the title of Fellow , under the guidance of Prof. R. Nicoletti . In 1977 he started at the University of New Brunswick (Canada) , a period of research under the guidance of Prof. K. Wiesner , earning his PhD in November 1979 . Since December 1979 resumed scientific and educational cooperation with Prof. R. Nicoletti at the University of Rome becoming a researcher . Winner of a bag NATO in 1985, he traveled for a year in laboratories of Prof. S. Hanessian of the ‘ University of Montreal (Canada) , as invited researcher .In October 1987 as an Associate Professor of Pharmaceutical Chemistry , he has held the chair of Analysis Pharmaceutical Chemistry III of the Degree Course in Pharmaceutical Chemistry and Technology of Faculty of Pharmacy, University of Siena and Bioorganic Chemistry for substitution at the Faculty of Mathematical, Physical and Natural Sciences. In the periods July-September 1987 – July September 1988 and from November to January 1989 he was Invited Professor at the University of Montreal (Canada). Since 2000 he is Full Professor of Pharmaceutical Chemistry at the University of Siena and holds the task of teaching Complements of Medicinal Chemistry and Synthesis and Design of Drugs for the Master of Science in Pharmaceutical Chemistry , University of Siena. In years 2002-2008 he held the position of Director of the Department of Drug Chemistry and Technology University of Siena. Prof. Botta was a member of the Board of the Division of Pharmaceutical Chemistry Society Italian Chemical from 1998 to 2004 , Director of the School ‘s annual ” Laboratory Methods Synthetic Medicinal Chemistry ” organizer of the workshop ” European Workshop on Drug Design ” , now in its seventh edition and ‘ ” European Workshop in Drug Synthesis ” , at the University of Siena and he is also a member of ‘ editorial board of scientific journalssuch as ” ChemMedChem ” , “Current Pharmaceutical Design” and ” Journal of Medicinal Chemistry ” . Since January 2008 he is Adjunct Professor at Temple University ‘s College of Science and Technology in Philadelphia (USA). The research group of Prof. Botta, currently consists of about 30 young people between undergraduates , graduate students,research grant and a single researcher , is active in the synthesis and structure determination of biologically active natural products , organic synthesis and testing of potential agents anti-viral and anti-cancer , anti-tuberculosis and synthesis of antifungal compounds . The techniques used to these studies can be summarized in conventional techniques for organic synthesis , synthesis techniques for small molecules in the solid phase , the use of enzymes , microwaves , and parallel synthesis, also molecular modeling techniques , such as docking , molecular dynamics , QSAR and 3D QSAR Virtual screening , generation of virtual libraries are used for the discovery and optimization of potential drugs . Recently, next to the chemical synthesis and Computational has also added the analytical chemistry for the determination of parameters Pharmacokinetic necessary for the optimization of pharmacologically active molecules . The scientific production of Professor Botta is summed up in about 460 publications in journals International , 15 patents and more than 150 conference papers .
MARIA JOSÉ CAMARASA obtained her PhD In Chemistry by the Universidad Complutense of Madrid. She was Head of the Chemotherapy Department of IQM-CSIC; Vice-Director of Medicinal Chemistry Institute (IQM-CSIC); President of the Spanish Society of Medicinal Chemistry (SEQT) (2004-2007); member of the executive board of the Chemistry Area of ANEP (2005-2008), coordinator of Medicinal Chemistry. She is actually Research Professor (Full professor) at the Medicinal Chemistry Institute of CSIC (IQM-CSIC), Madrid, Spain; co-coordinator of the Chemical Science and Technologies area of the CSIC; Head the of nucleosides and analogues group and Member of the executive board of International Society for Nucleosides, Nucleotides and Nucleic Acids (IS3Na). She was awarded in 2001 with the prestigious René Descartes-Prize of the European Commission. Her research interests are the Medicinal Chemistry, drug-design and discovery, antivirals, anticancer, antiinfectives, pro-drugs, organic chemistry, carbohydrates, nucleosi(ti)des, peptides.
ROBERTO DI SANTO Graduated in Chemistry in 1986 – “La Sapienza” University of Rome and from 1988 had a scholarship in the Pasteur Institute –Fondazione Cenci Bolognetti, Università degli Studi di Roma “La Sapienza”. In 1994 graduated in Pharmacy cum laude at “La Sapienza” University of Rome. From 1996 was Researcher SSD C07x-in Pharmaceutical Chemistry and from 1998 became associate professor. He as multiple research topics, among which chemioterapeutic drugs and antiviral drugs (HIV, HCV, Chicungunya, polio, influenza). He works also on neuroactive compounds (anti-Alzehimer).
ERIC FREED received his Ph.D. in 1990 in the laboratories of Drs. Rex Risser and Howard Temin at the University of Wisconsin-Madison and did postdoctoral work with Dr. Temin at UW-Madison in 1991. His work in Madison focused on the function of the murine leukemia virus and HIV envelope glycoproteins in membrane fusion and virus entry. He joined the Laboratory of Molecular Microbiology at the National Institute of Allergy and Infectious Diseases (LMM/NIAID) in 1992, where he worked with Dr. Malcolm Martin on a variety of topics relating to virus assembly and entry/post-entry events in the HIV replication cycle. In 1997, he was appointed as a Tenure-Track Investigator in LMM/NIAID, and he was promoted to a tenured Senior Investigator position in 2002. Dr. Freed joined the HIV Drug Resistance Program in 2003. He was an organizer of the 2004 Cold Spring Harbor Retroviruses conference, 2006 ASCB Cell Biology of Retroviruses conference, and 2012 Keystone Conference “Frontiers in HIV Pathogenesis, Therapy and Eradication.” In 2009, he was appointed as the first Editor-in-Chief of Viruses; he also currently serves on the Editorial Boards of Journal of Virology, Virology, Open Virology Journal, Retrovirology, Advances in Virology, Frontiers in Virology, and Journal of Molecular Biology. Dr. Freed was selected as an NCI Mentor of Merit in 2010 for excellence in mentoring and guiding the careers of trainees in cancer research, and he was appointed to the NCI Senior Biomedical Research Service in 2011. He is currently serving as the Chair of the NIH Virology Interest Group, a member of the NIH AIDS Discovery and Development of Therapeutics study section, and an organizer for the 2014 Keystone Conference “Viral Entry, Assembly, Exit and Spread.” He also currently serves as an adjunct Professor in the Department of Cell Biology and Molecular Genetics at the University of Maryland, College Park and is Co-director of the University of Maryland Virology Program.
FEDERICO GAGO studied Pharmacy at Complutense University, Madrid, and followed post-doctoral studies at the Physical Chemistry Laboratory, Oxford University, under the supervision of Prof. W. Graham Richards. He teaches Pharmacology at the Schools of Pharmacy and Medicine in the University of Alcalá (Madrid), one of the oldest European universities, where he is a Full Professor in the Department of Biomedical Sciences. He was Associate Director of the NFCR Center for Computational Drug Design (Oxford) from 2001 to 2006 and a member of the Editorial Advisory Board of Journal of Medicinal Chemistry from 2006 to 2010. Since 2001 he has been serving as an Editor-in-Chief for Journal of Computer-Aided Molecular Design and as a member of the Editorial Advisory Board for Anti-Cancer Agents in Medicinal Chemistry (formerly Current Medicinal Chemistry – Anti-Cancer Agents). Prof. Gago has authored more than 150 research papers in specialized scientific journals and has published several reviews and book chapters. His research interests are in the areas of structure-based drug design, receptor-based structure-activity relationships, and computer simulations of drug-targeted biomolecular systems including DNA, enzymes and pharmacological receptors.
REUBEN HARRIS is a Professor in the Biochemistry, Molecular Biology and Biophysics department, an Associate Director of the Institute of Molecular Virology, and a Member of the Masonic Cancer Center. He received his B.S. (1993) and Ph.D. (1997) degrees from the University of Alberta in Edmonton, Canada. He performed postdoctoral work at the Baylor College of Medicine (1997-8), at Yale University (1998), and at the Medical Research Council Laboratory of Molecular Biology (1998-2003). He joined the University of Minnesota as an Assistant Professor in the summer of 2003, became a tenured Associate Professor in 2008, and was promoted to Full Professor in 2013. As a Postdoctoral Fellow in Cambridge working with Dr. Michael Neuberger, Dr. Harris discovered a family of cellular enzymes that catalyze the conversion of the DNA base cytosine into the RNA base uracil. One member of this family is essential for generating antibody diversity (adaptive immunity) and several combine to provide protection from a wide variety of parasitic elements such as HIV (innate immunity). At least one member also becomes dyregulated in multiple human cancers and provides a major source of mutations. Dr. Harris has done pioneering studies in all of these important areas, thus far publishing over 100 manuscripts, filing 10 patents, and co-founding a company. He continues to run an academic research laboratory with multiple projects focused on the roles of these enzymes in immunity and carcinogenesis.
MAMUKA KVARATSKHELIA is a Professor of Pharmaceutical Sciences at the Ohio State University. He received his Ph.D. and postdoctoral training studying structural and functional properties of DNA modifying enzymes in Republic of Georgia and United Kingdome, respectively. Dr. Kvaratskhelia continued his research career in Dr. Le Grice’s laboratory, where he developed the mass spectrometry-based protein footprinting approach to map nucleic acid and inhibitor binding sites on HIV-1 proteins. Since 2003 Dr. Kvaratskhelia has been a faculty member at the Ohio State University College of Pharmacy. He is a recipient of the NIH Research Career Development Award (2007-2012) and currently serves as a member of the AIDS Discovery and Development of Therapeutics study section. The primary focus of Dr. Kvaratskhelia’s research group has been to better understand HIV-1 integrase structure and function as a therapeutic target and develop novel allosteric inhibitors with potent antiviral activities. His group identified a new class of small molecules that promote aberrant, higher order multimerization of HIV-1 integrase and potently inhibit HIV-1 replication. In addition, his group has elucidated structural and mechanistic foundations of how LEDGF/p75, a key cofactor of HIV-1 integrase, directs HIV-1 preintegration complexes to actively transcribed genes. More recently, Dr. Kvaratskhelia’s group has discovered BET proteins as cofactors of murine leukemic virus (MLV) integrase and demonstrated their significance for effective MLV integration at transcription start sites. These studies have opened up a new path for improving the safety of MLV based vectors for human gene therapy.
STUART LE GRICE received his Ph.D. from the Department of Biochemistry, University of Manchester, UK, in 1976, where he studied the mechanisms of R-factor-mediated multidrug resistance in Escherichia coli. After postdoctoral training in the United Kingdom, Germany, and the United States, he was appointed Senior Scientist in the Central Research Units of Hoffmann La Roche, Basel, Switzerland, where he worked from 1984 to 1990 evaluating HIV-1 and HIV-2 enzymes as therapeutic targets. In 1990, he joined the faculty in the Division of Infectious Diseases, Department of Medicine, Case Western Reserve University (CWRU), Cleveland, OH. Initially recruited as an Associate Professor of Medicine, he was awarded tenure in 1992, and in 1995 was promoted to Professor of Medicine, Biochemistry, and Oncology. From 1994 to 1999, he served as Director of the NIH-funded CWRU Center for AIDS Research. Dr. Le Grice joined the National Cancer Institute in 1999 as Chief of the Resistance Mechanisms Laboratory in the HIV Drug Resistance Program, Center for Cancer Research (CCR), and in 2005 was appointed to the Senior Biomedical Research Service. In 2006, he was appointed Head of the Center of Excellence in HIV/AIDS & Cancer Virology, CCR. He is a member of the CCR HIV and Cancer Virology faculty, Chemistry and Biology faculty, and the Steering Committee of the Molecular Targets Discovery Program. In addition to serving on the Editorial Board of the Journal of Biological Chemistry, Dr. Le Grice has been an ad hoc (1990-1999) and permanent Study Section member of NIH AIDS review panels (2000-2004), as well as an ad hoc reviewer for several international funding agencies.
FRANCO LORI founded ViroStatics in 2005, serving as President and Chief Executive Officer. With 20 years of extensive experience in Biotech management, Dr. Lori has overseen the successful start-up of three biotechnology companies. Dr. Lori also has experience in investigative preclinical and clinical research interacting with a network of clinical, pharmaceutical, government, and basic science researchers in the USA, Europe, South America, and Africa.
In 2000, Dr. Lori was recognized as a global “Hero in Medicine” for his achievements in HIV therapy. He has co-authored over 100 international peer-reviewed publications. Dr. Lori received his MD from the University of Parma and earned his PhD degree at the University of Pavia, Italy. He was Senior Investigator in the Laboratory of Tumor Cell Biology at the National Cancer Institute before co-founding RIGHT in 1994 where he serves as Board Director.
Fields of interest: drug development, nanotechnology, precision medicine, incurable diseases
PETER MATYUS achieved his M.S. in Synthetic Organic Chemistry at in 1975; the M. Litt. (Doctor title) in 1980; and the Degree in Medicinal Chemistry at the Technical University Budapest 1981. He obtained his habilitation at the A. Szent-Györgyi Univ., Szeged on 1997; and the C.Sc., D.Sc. at the Hungarian Academy of Sciences. He pursuived with several Postdoctoral Fellowships of the A.v. Humboldt-Foundation (Inst. für Organische Chemie und Biochemie), University of Bonn (H. Wamhoff) (1982-1984, 1989, 1990); of the Ciba-Geigy Foundation for Promotion of Sciences Japan (Inst. for Chem. Res.), University of Kyoto (K. Tanaka) 1992-93; and the fellowship of the Australian Natl. University (John Curtin School of Medical Research) (G. Barlin) Canberra 1993 (1 month), and on 1994 (3 months). From 1997 he is the Head of the Department of Organic Chemistry at the Semmelweis University. Since 2008 he is the Director of the Drug Discovery and Safety Centre at the Semmelweis University. His memberships: 1999-2007 Chair of the Division of Organic and Medicinal Chemistry of the Hungarian Chemical Society (re-elected twice); 2007-2011 President of the Hungarian Chemical Society; 2002-2006 Member of the Council of Scientists, INTAS (EU, Brussels; re-elected); International Advisory Board of ChemMedChem. Associate Editor of Future Med. Chem; 2004-2010 Member of the Executive Committee, and Chair of Education and Training Committee of European Federation for Medicinal Chemistry (re-elected); Member of Medicinal Chemistry Subcommittee of IUPAC; Member of ACS; Founder and Board member of Paul Ehrlich MedChem Euro-PhD Network. He also won several awards such as: Zemplén-Prize, Hungarian Academy of Sciences 1989; ‘Nívó’-Prize, Hungarian Chemical Society, 1996. Genius Prize, Committee of the Hungarian Inventors, (twice) 1996, 1998; Jedlik Ányos Prize, Hungarian Patent Office, 2002; Kazay Prize, Hungarian Pharmaceutical Society, 2004; Than Károly Prize, Hungarian Chemical Society, 2005; Náray-Szabó Gábor Prize, Hungarian Chemical Society, 2006; Bruckner Prize, Hungarian Academy of Sciences 2009; PhD-Educational Prize, Semmelweis University, 2011. His research interests are medicinal chemistry of cardiovascular and central nervous systems, molecular modelling and synthesis of biologically active compounds; synthetic and mechanistic chemistry of pyridazines and nitrogen containing heterocycles.
THOMAS MERTENS studied Chemistry in Bonn and Medicine in Cologne (1968-1976). He obtained the MD Thesis (Dr. med.) on 1976 and his Habilitation on 1984. Thomas Mertens was medical assistant, training in internal medicine and surgery (1976–1977); he continued with a research fellowship for the postdoctoral training in immunology, virology and diagnostics, Institute of Virology, University of Cologne (1977–1985). In 1983 he reached the Board Certification in Microbiology and Epidemiology of Infectious Diseases. In 1985 he became Professor (C2) at the Institute of Virology, University of Cologne, from 1991 to 1998 he was Professor (C3), in the Dept. of Virology, Ulm University. He was Temporary Director of the Dept. Medical Hygiene, Ulm University Hospital from 1991 to 1992; and Dean of Studies at the Medical Faculty, Ulm University from 2003 to 2006. Since 1998 he is the Director of the Institute of Virology at the Ulm University Hospital. His research focuses: mechanisms of resistance of antiviral substances towards herpes viruses; the analysis of the biological function of the viral gene UL97; new targets for antiviral interference against human cytomegalovirus (HCMV); molecular mechanisms and functional relevance of host-cell genes modulation by HCMV; viral tegument proteins and Morphogenesis of HCMV; new organ culture model for analysis of HCMV infection; the characterization and function of G-protein coupled receptor homologs of HCMV; and the Clinical Virology.
GIORGIO PALÙ received his M.D. degree from the University of Padova (1973) and the Specialty diplomas in Oncology (1976) and General Pathology (1978) from the University of Pavia. He worked as a Postdoctoral Fellow and Research Associate at the Tumor Institute, Jules Bordet, Université Libre, Bruxelles (1975), the Chester Beatty Research Institute-Royal Marsden Hospital, Royal Cancer Institute, London University, UK (1976-79), the Department of Pharmacology, Yale University, New Haven, CT (1980).Assistant Professor in Microbiology, University of Parma (1980-82); Associate Professor in Virology, University of Padova (1983-1989); Visiting Professor, Department of Molecular Biochemistry and Biophysics, Yale University, 1982,1984,1986; Division of Virology, National Institute for Medical Research, Mill Hill, London, UK, 1980,1985,1987; Division of Human Retrovirology, Dana Farber Cancer Institute, Harvard Medical School (1990), Full Professor of Microbiology and Virology (since 1989), University of Padova. Director at the University of Padova: Institute of Microbiology (1991-1999); Department of Histology, Microbiology and Medical Biotechnologies, (1999-2002); Department of Molecular Medicine (since 2012); Head of the Padova GMP Cell-factory and of the Unit of Clinical Microbiology and Virology, Padova University Hospital (since 1996). Coordinator, PhD Course/School in Virology (since 1998) and in Biomedicine (since 2007); Member of the Board of the International PhD Programmes in Molecular Medicine, University of Ulm, Germany (since 2008), in Biomedicine and Translational Neurosciences, Temple University, Philadelphia, USA (since 2011); Adjunct Professor at the Medical School and at the Faculty of Sciences, University of Temple; Pro-Rector, University of Padova (2002-2004); Dean, Faculty of Medicine, University of Padova (2004-2011). GP has also served as a member of the scientific-technical Committee of the Italian Drug Agency (AIFA), of the directory Board of the Italian AIDS Commission, of the Istituto Superiore di Sanità (Rome) and of the Institute of Human Virology (Baltimore). Professor Palù is the running President of the European Society for Virology. Giorgio Palù has long-standing experience in the study of pathogenesis of viral infections and the design of viral and non-viral vectors for gene transfer, somatic gene therapy and vaccinology. He has made relevant contributions to the study of antimicrobial therapy and resistance and anticancer therapy with more than 400 publications and 10 patents. His basic research has provided a platform for finding new targets for antiviral therapy and new antivirals based on peptides and small molecules able to disrupt the interface of protein-protein interactions essential for viral replication.
CARLO FEDERICO PERNO is Professor of Virology at the University ‘of Rome Tor Vergata and Primary Unit’ Complex Molecular Virology, Policlinico Tor Vergata. Pin is also director of the School of Specialization in Microbiology and Virology. He graduated in 1980 in Medicine, Universita ‘di Roma “La Sapienza” with honors, in 1983 specializes in Oncology.
From 1986 to 1989 he was Assistant Professor at the National Cancer Institute. He works in the field of ‘AIDS since 1985, and has contributed to the discovery of some of the drugs still used for the treatment of HIV infection. He is a fellow of numerous research funds obtained from various public and private institutions, including EEC, CNR, Ministry of Health ‘, Ministry of University’ and Research, UNESCO, aimed at scientific and clinical research mainly on viral infections. Author of more ‘than a thousand scientific articles and presentations at international conferences. He received the 2001 Descartes Prize of the Community ‘European Excellence Research.
VINCENZO SUMMA Head of Chemistry IRBM Science Park spa from February 2010. IRBM Science Park is a research centre formally a spin-off of the Merck Research Laboratories locate in Rome. He graduated in Chemistry at Università degli Studi di Roma ‘La Sapienza’ in 1991 and in 1996 obtained his Ph.D in Organich Chemistry at Bergische Universität Wuppertal. From 1992 to 1994 was researcher at University of Rome “La Sapienza” . He became Research Fellow Merck from March 1996 to August 2001 . Here was promoted Senior Research Fellow (September 2001 );Senior Investigator Merck (November 2005 ) and Director in the medicinal chemistry department from November 2007to October 2009. From June 2010 is Associate Researcher CNR-ITB National Research Council – Institute for Biomedical Technologies and from April 2013 Member of the Board of Directors at CNCCS Consortium (IRBM SP – Consiglio Nazionale delle Ricerche – Istituto Superiore di Sanità)
BIRGITTA M. WÖHRL studied biology in Regensburg, Germany and in Cardiff, UK. She obtained her doctoral degree in bacterial genetics from the University of Osnabrück, Germany, in 1989. During her postdoctoral training at the Max-Planck-Institute for Genetics in Berlin and at Case Western Reserve University, Cleveland, Ohio, she worked on biochemical aspects of retroviral reverse transcriptases. In 1992 she was awarded a five year “AIDS-stipend” from the German Ministry of Education and Research. She joined the Max-Planck-Institute for Molecular Physiology in Dortmund, Germany in 1994 working on retroviral replication, AZT resistance and genetically engineered thymidylate kinases. In 2002 she received a position at the University of Bayreuth, Germany in the Department of Biopolymers and was promoted to Professor in 2005. Her research interests include the structure and function of retroviral enzymes, and of viral and cellular factors involved in HIV transcription, the elucidation of resistance mechanisms against antiviral drugs, the mechanism of action of antiviral compounds, and the replication of foamy viruses.
Antonella ARRIDU University of Cagliari, Italy
Jessica BOGS Federal Research Institute for Animal Health, Germany
Marta CADEDDU University of Cagliari, Italy
Roberta CADONI University of Sassari, Italy
Arianna CALISTRI University of Padua , Italy
Valeria CANNAS University of Cagliari,Italy
Ilaria CARLI University of Padua, Italy
Michele CELESTINO University of Padua, Italy
Laura CONTARDI University of Parma, Italy
Angela CORONA University of Cagliari, Italy
Gianluca DAINO University of Cagliari, Italy
Laura DE LUCA University of Messina, Italy
Claudia DEL VECCHIO University of Padua, Italy
Ruth DEME Semmelweis University, Budapest
Simona DISTINTO University of Cagliari
Francesca ESPOSITO University of Cagliari, Italy
Nicole GRANDI University of Cagliari, Italy
Pouya HASSANDARVISH Faculty of Medicine, Kuala Lumpur,Malaysia
Samira KHIAR Institut Pasteur de Paris, France
Florencia NataliaLINERO Inflammation Research Center (IRC), Belgium
Valentina Noemi MADIA Università la Sapienza Roma,Italy
Riccardo MARTINI University of Siena, Italy
Serena MASSARI University of Perugia, Italy
Elena MATYUGINA Engelhardt Institute of Molecular Biology RAS Moscow, Russia
Rita MELEDDU University of Cagliari, Italy
Antonella MESSORE Università la Sapienza Roma,Italy
Monica MEOLA Istituto Superiore di Sanità, Italy
Marta MURREDDU Georgetown UniversityWashington,USA
Vasanthanathan POONGAVANAM University of Southern Denmark
St Patrick REID USAMRIID Frederick, MD,USA
Udaya Pratap SINGH Institute of Agriculture, Technology & Sciences, India
Axel SCHUBERT Ulm University Medical Center,Germany
Lora SIMEONOVA Bulgarian Academy of Sciences,Sofia, Bulgaria
PavelSOLYEV Russian Academy of Sciences,Moscow,Russia
ŁukaszŚWIĄTEK Medical University of Lublin,Poland
Oriana TABARRINI University of Perugia, Italy
Maria ElenaTERLIZZI Università degli Studi di Torino, Italy
Graziella TOCCO University of Cagliari , Italy
Marta TOFFOLETTO University of Padua, Italy
Janne TYNELL National Institute for Health and Welfare Helsinki,Finland
Finny VARGHESE University of Helsinki, Finland
Teoria strutturale: Introduzione alla Chimica Organica. Teoria strutturale, elettroni di valenza e valenza, legami chimici, formule di Lewis, legame ionico e covalente. Concetto di elettronegatività. Orbitali atomici e molecolari. Teoria della risonanza. Configurazione elettronica del carbonio. Ibridazione sp3. sp2 e sp. Legame sigma e pi-greco. Come si scrivono le molecole: formule molecolari, formule di struttura, formule di Lewis, formule condensate, semi-condensate e a zig-zag. Concetto di gruppo funzionale. Classificazione degli atomi di carbonio e idrogeno.
Reazioni: omolitiche e eterolitiche, ioniche e radicaliche. Formazione di radicali, carbocationi e carboanioni. Specie elettrofile e nucleofile. Energia di dissociazione dei legami. Reazioni esotermiche ed endotermiche.
Alcani e cicloalcani: struttura, proprietà fisiche, fonti principali. Isomeri strutturali. Analisi conformazionale degli alcani e dei cicloalcani: tensione sterica, torsionale e angolare. Conformazioni e configurazioni. Legami assiali e equatoriali. Interazione 1,3-diassiale. Nomenclatura IUPAC: alcani, gruppi alchilici, bicicli e spirani.
Preparazione: 1) idrogenazione degli alcheni e degli alchini; 2) riduzione di alogenuri alchilici con metalli e acidi; 3) idrolisi dei reattivi di Grignard; 4) reazione di Wurtz.
Reazioni: ossidazione, sostituzioni radicaliche, alogenazione radicalica (meccanismo), stabilità dei radicali.
Stereochimica: definizione di isomero, isomeri costituzionali, isomeri geometrici, stereoisomeri, enantiomeri, diastereoisomeri, concetto di chiralità, regole di Cahn, Ingold e Prelog. Polarimetro ed attività ottica, luce polarizzata linearmente, sostanze levogire e destrogire, miscela racemica, molecole con più stereocentri, composti meso, nomenclatura di molecole con più stereocentri, formule di Fischer e tridimensionali. Purezza ed eccesso enantiomerico. Risoluzione ottica di miscele racemiche,
Alcheni: formula generale. Proprietà fisiche, nomenclatura IUPAC. Isomeria geometrica cis/trans e E/Z, stabilità.
Preparazione: 1) deidroalogenazione di alogenuri alchilici; 2) disidratazione degli alcoli; 3) dealogenzione dialogenuri vicinali; 4) riduzione degli alchini; 5) reazione di Wittig.
Reazioni: addizione elettrofila e radicalica, meccanismo. Regola di Markovnikov. 1) Addizione di acidi alogenidrici in presenza e in assenza di perossidi; 2) addizione di acqua; 3) addizione di alogeni; 4) formazione di aloidrine; 5) idrogenazione catalitica e calore di idrogenazione; 6) ossimercuriazione-demercuriazione; 7) idroborazione-ossidazione; 8) epossidazione; 9) ossidrilazione per trattamento con KMnO4 o OsO4; 10) ossidazione con KMnO4 o con ozono;
Dieni Coniugati: Generalità: struttura e confronto di stabilità tra dieni isolati, coniugati e cumulati. Addizioni elettrofile: controllo cinetico e termodinamico.
Alchini: formula generale. Proprietà fisiche. Ibridazione. Acidità degli alchini terminali. Nomenclatura IUPAC.
Preparazione: 1) deidroalogenazione di dialogenuri alchilici; 2) alchilazione di alchini terminali.
Reazioni: 1) sintesi di alcheni per addizione di idrogeno con il catalizzatore di Lindlar (addizione sin); 2) sintesi di alcheni per reazione con Na o Li in NH3 (addizione anti); 3) addizione di acidi alogenidrici; 4) addizione di acqua con formazione degli enoli; 5) addizione di alogeni; 6) sintesi di alchini superiori a partire da acetiluri. Tautomeria cheto-enolica.
Alogenuri alchilici: proprietà e usi. Nomenclatura IUPAC.
Preparazione: 1) sostituzione nucleofila degli alcoli; 2) alogenazione degli alcani; 3) addizione di acidi alogenidrici agli alcheni; 4) addizione di alogeni agli alcheni.
Reazioni: 1) Sostituzione nucleofila alifatica; 2) reazione di eliminazione: deidroalogenazione di alogenuri alchilici e dealogenzione di di alogenuri vicinali; 3) formazione dei reattivi di Grignard; 4) riduzione con metalli e acidi
Carbocationi, Carboanioni e radicali: definizione, formazione, stabilità, trasposizione e reattività.
Sostituzione Nucleofila Alifatica: definizione di nucleofilicità e di basicità. Meccanismi SN1 e SN2 e fattori che influenzano le loro velocità relative (struttura del substrato, concentrazione e reattività del nucleofilo, effetto del solvente, effetto del gruppo uscente). Confronto fra Sn1 e Sn2.
Reazioni di Eliminazione: Meccanismi E1 e E2. Regioselettività: regola di Saytzeff. Fattori che influenzano le reazioni di eliminazione: substrato, base, solvente e gruppo uscente. Cinetica e stereochimica. Fenomeni di riarrangiamento nelle E1. Confronto fra E1 ed E2. Competizione tra reazioni SN1 ed SN2 e tra E1 ed E2: Deidroalogenzione di alogenuri alchilici. Disidratazione di alcoli. Dealogenazione di di alogenuri vicinali .
Teoria della Risonanza: strutture limiti e ibrido di risonanza. Come disegnare le strutture limiti di risonanza. Energia di risonanza.
Alcoli: struttura, proprietà fisiche, legami H, solubilità in acqua, acidità. Nomenclatura IUPAC e corrente.
Preparazione: 1) addizione di acqua agli alcheni; 2) ossimercuriazione-demercuriazione; 3) idroborazione-ossidazione; 4) reazione dei composti carbonilici con i reattivi di Grignard; 5) riduzione di aldeidi, chetoni; 6) riduzione di acidi ed esteri; 7) reazione degli epossidi con i reattivi di Grignard; 8) sostituzione nucleofila degli alogenuri alchilici; 9) ossidrilazione degli alcheni per ottenere i glicoli.
Reazioni: acidità e basicità degli alcoli, formazione degli ioni alcossido. 1) sostituzione nucleofila degli alcoli; 2) disidratazione ad alcheni; 3) ossidazione ad aldeidi, acidi e chetoni ; 4) sintesi degli esteri per reazione con acidi e con alogenuri acilici; 5) sintesi di Williamson.
Eteri, epossidi, tioli e solfuri: struttura, proprietà fisiche, legami H, solubilità in acqua, acidità. Nomenclatura IUPAC e corrente.
Preparazione degli Eteri: 1) sintesi di Williamson; 2) disidratazione degli alcoli.
Reazioni degli Eteri: reazione degli eteri con acidi forti.
Preparazione degli Epossidi: 1) epossidazione degli alcheni; 2) dalle aloidrine.
Reazioni degli Epossidi 1) apertura dell’anello mediante catalisi acida; 2) apertura dell’anello mediante catalisi basica; 3) reazione con i reattivi di Grignard.
Preparazione e reazioni dei Tioli e dei Solfuri: 1) sostituzione nucleofila degli alogenuri alchilici; 2) sintesi di Williamson; : ossidazione dei tioli a disolfuri
Composti aromatici: definizione, struttura del benzene, formule di Kekulè, energia di risonanza e stabilità, orbitali molecolari, regola di Huckel, nomenclatura dei derivati del benzene.
Sostituzioni elettrofile aromatiche: generalità, confronto con gli alcheni. Meccanismo. Alogenazione, nitrazione, solfonazione, alchilazione e acilazione di Friedel-Crafts (limitazioni e utilità sintetiche). Effetto dei sostituenti sulla reattività dei benzeni mono e di-sostituiti. Gruppi attivanti e disattivanti, orto/para e meta-orientanti. Effetto induttivo e mesomero. Reattività e orientamento degli alogeni. Orientamento della sostituzione elettrofila nei benzeni di-sostituiti, effetto sinergico, limitazioni delle sostituzioni in presenza di gruppi a forte attrazione elettronica e in presenza di gruppi amminici. Sintesi regioselettive
Areni: alchil, alchenil e alchinil benzeni. Nomenclatura.
Preparazione: 1)alchilazione di Friedel-Crafts; 2) trasformazione della catena laterale. Reazioni: 1) alogenazione del carbonio benzilico; 2) ossidazione della catena laterale.
Aldeidi e Chetoni: gruppo carbonilico, nomenclatura IUPAC e corrente, proprietà fisiche.
Preparazione aldeidi: 1) ossidazione degli alcoli primari; 2) riduzione dei cloruri degli acidi; 3) riduzione degli esteri e dei nitrili; 4) reazione di Reimer-Tiemann; 5) ozonolisi degli alcheni; 6) reazione di Gatterman-Koch.
Preparazione chetoni 1) ossidazione degli alcoli secondari; 2) acilazione di F.C; 3) sintesi acetacetica; 4) addizione di acqua agli alchini; 5) ozonolisi degli alcheni; 6) ossidazione con permanganato degli alcheni.
Reazioni: addizione nucleofila al carbonio acilico, meccanismo, catalisi acida, stereochimica. 1) Addizione di HCN, cianidrine come intermedi di sintesi; 2) addizione di acqua in ambiente acido e basico; 3) addizione di alcoli e formazione di acetali e chetali, emiacetali ciclici, acetali e chetali come gruppi protettori; 4) addizione di acetiluri; 5) addizione dei reattivi di Grignard; 6) addizione di ammine e derivati, formazione di immine (basi di Schiff) e di enammine, meccanismo, ammirazione riduttiva; 7) addizione delle ilidi del fosforo-reazione di Wittig; 8) reazione di Cannizzaro. Ossidazione delle aldeidi, ossidazione di aldeidi e chetoni con peracidi – reazione di Baeyer-Villinger. Riduzione ad alcoli con H2 e catalizzatori e con idruri metallici (NaBH4, LiAlH4). Riduzione ad idrocarburi; riduzione di Clemmensen e di Wolff-Kishner, meccanismo.
Reazioni aldoliche: Acidità degli H in alfa al carbonile. Enoli ed enolizzazione. Tautomeria cheto-enolica, catalisi acida e basica. Formazione di enoli nei composti dicarbonilici. Alfa-alogenazione di aldeidi e chetoni. Reazione aloformica. Condensazione aldolica e condensazione aldolica incrociata. Disidratazione delle beta-idrossi aldeidi e dei beta-idrossi chetoni.
Composti carbonilici alfa-beta insaturi: addizione diretta al carbonio carbonilico (1,2), addizione coniugata al carbonio in beta (1,4). Addizione di Michael. Addizione di Diels-Alder.
Acidi Carbossilici: gruppo carbossilico, nomenclatura IUPAC e corrente, proprietà fisiche. Acidi grassi saturi e insaturi, proprietà fisiche. Omega 3 e omega 6. Acidi grassi idrogenati. Acidità degli acidi carbossilici, influenza dei sostituenti sulla acidità.
Preparazione: 1) ossidazione degli alcoli primari; 2) ossidazione delle aldeidi; 3) ossidazione dei metilchetoni; 4) ossidazione degli areni; 5) ozonolisi degli alcheni; 6) ossidazione con permanganato degli alcheni; 7) carbonatazione dei reattivi di Grignard; 8) idrolisi dei nitrili; 9) idrolisi delle cianidrine; 10) idrolisi dei derivati degli acidi carbossilici; 11) sintesi di Kolbe. Preparazione dell’Aspirina; 12) sintesi malonica.
Reazioni: 1) Acidità e formazione dei sali; 2) sostituzione nucleofila al carbonio acilico, meccanismo, confronto con l’addizione nucleofila delle aldeidi e dei chetoni, sintesi dei derivati degli acidi carbossilici; 3) riduzione ad alcoli primari; 4) reazione di Hell-Volhard e Zelinsky; 5) sostituzioni elettrofile aromatiche degli acidi benzoici.
Derivati degli acidi carbossilici:sostituzione nucleofila al carbonio acilico, meccanismo.
Cloruri acilici: nomenclatura
Preparazione:dagli acidi carbossilici
Reazioni: 1) reazione di idrolisi ad acidi carbossilici; 2) reazione di alcolisi ad esteri; 3) reazione di ammonolisi ad ammidi; 4) sintesi di anidridi; 5) acilazione di Friedel-Crafts; 6) riduzione ad aldeidi.
Preparazione: 1) dagli acidi carbossilici; 2) dai cloruri acilici
Reazioni: 1) reazione di idrolisi ad acidi carbossilici; 2) reazione di alcolisi ad esteri; 3) reazione di ammonolisi ad ammidi, immidi da anidridi cicliche 4) acilazione di Friedel-Crafts;
Preparazione: 1) dagli acidi carbossilici, esterificazione di Fischer; 2) dai cloruri acilici; 3) dagli esteri per reazione di trans esterificazione; 4) dalle anidridi.
Reazioni: 1) reazione di idrolisi ad acidi carbossilici, saponificazione; 2) reazione di ammonolisi ad ammidi; 3) riduzione ad alcoli; 4) riduzione ad aldeidi; 5) reazione con i reattivi di Grignard; 6) reazione di Claisen.
Preparazione: 1) dagli acidi carbossilici; 2) dai cloruri acilici; 3) dagli esteri 4) dalle anidridi.
Reazioni: 1) reazione di idrolisi ad acidi carbossilici; 2) riduzione ad ammine; 3) formazione di immidi; 4) formazione di nitrili; 5) degradazione di Hofmann, meccanismo.
Composti beta-dicarbonilici: enolizzazione, acidità degli idrogeni in alfa.
Reazioni: 1) condensazione di Claisen e Claisen incociata; 2) condensazione di Dieckmann; 3) idrolisi e decarbossilazione dei beta-chetoesteri; 4) sintesi malonica; 5) sintesi acetacetica; 6) reazione di Knovenagel; 7) reazione di Michael; 8) reazione di Mannich.
Fenoli: nomenclatura, proprietà fisiche, acidità, confronto con gli alcoli, fattori che influenzano l’acidità dei fenoli.
Preparazione: 1) dagli acidi benzensolfonici; 2) dall’idroperossido di cumene; 3) dai sali di diazonio; 4) dagli alogenuri arilici.
Sostituzione nucleofila aromatica: meccanismo di addizione-eliminazione e di eliminazione-addizione via benzino.
Reazioni: 1) formazione dei fenossidi; 2) sostituzione elettrofila aromatica, trasposizione di Fries; 3) reazione di Kolbe; 4) reazione di Reimer-Tiemann.
Alogenuri arilici: nomenclatura, proprietà fisiche
Preparazione: 1) alogenazione del benzene; 2) dai Sali di diazonio.
Reazioni: 1) formazione dei reattivi di Grignard; 2) sostituzione elettrofila aromatica; 3) sostituzione nucleofila aromatica.
Ammine: struttura, classificazione, Nomenclatura IUPAC e comune, proprietà fisiche, ibridazione dell’azoto. Basicità delle ammine e fattori che influenzano la basicità. Confronto tra la basicità delle ammine alifatiche e aromatiche. Formazione dei Sali di ammonio.
Preparazioni: 1) ammonolisi degli alogenuri alchilici; 2) riduzione dei nitrocomposti; 3) riduzione di ammidi; 4) riduzione di nitrili; 5) amminazione riduttiva; 6) sintesi di Gabriel; 7) degradazione di Hofmann.
Reazioni: 1) alchilazione-ammonolisi ; 2) sintesi delle ammidi, legame peptidico nelle proteine; 3) sostituzione elettrofila aromatica; 4) reazione con l’acido nitroso: formazione dei sali di diazonio e delle N-nitrosammine; 5) reazione dei sali di ammonio quaternari, eliminazione secondo Hofmann, meccanismo e regio selettività, confronto con l’eliminazione secondo Saytzeff.
Sali di diazonio: Reazioni di Sandmeyer con alogenuri rameosi, sintesi degli ioduri e dei fluoruri arilici; sintesi dei nitrili aromatici e dei fenoli; reazione di deamminazione. Reazione di diazocopulazione.
Chimica dei composti eterociclici: generalità, classificazione, aromatici e non, nomenclatura IUPAC e corrente. Aromaticità: energia di risonanza, sistemi elettron-ricchi ed elettron-poveri. Basicità, acidità e reattività verso le sostituzioni elettrofile e nucleofile aromatiche. Piridina: Reazione di Chichibabin, riduzione dell’anello piridinico e ossidazione delle catene laterali. Chinolina e isochinolina. Diazine: Basi pirimidiniche. Pirrolo e nucleo porfirinico. Indolo. Azoli: Imidazolo, basi puriniche. Furano e tiofene.
Chimica Organica – Brown-Foote EdiSES
Chimica Organica – Solomons J. Wiley & Sons
Chimica Organica – J. McMurry PICCIN
Chimica Organica – Bruice EdiSES
Chimica Organica – Smith McGraw-Hill
Chimica Organica – Morrison-Boyd Casa Ed. Ambrosiana